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:: Volume 6, Issue 6 (1-2012) ::
3 2012, 6(6): 0-0 Back to browse issues page
Expression Levels of Th-2 and Th-17 Characteristic Genes in Healthy Tissue Versus Periodontitis
Parichehr Behfarnia , Reza Birang , Seyed Sajad Pishva , Mazdac Ghanjali Hakemi , Mitra Mohammadi Khorasani *
Abstract:   (2117 Views)
Objective: The T helper 17 (Th17) cells have been suggested to have osteoclast activating effects while T helper 2 (Th2) cells are considered to have an osteoprotective role in periodontitis. This study was to compare the markers of Th17 cells (RORC2 and IL-17 genes) with that of Th2 cells (IL-4 and GATA-3 genes) between healthy and periodontitis tissues.
Materials and Methods: The samples were obtained from patients with periodontitis and healthy tissues. The mRNA expression levels of IL-17, RORC2, IL-4 and GATA-3 were measured in both groups using quantitative RT-PCR. The results were compared using SPSS 11.0. Correlation coefficient was analyzed by Spearman’s rho test. Mann-Whitney was used to measure the difference between IL-17 and IL-4 as well as RORC2 and GATA-3.
Results: In periodontal lesions, the expression levels of all markers were significantly higher than the healthy tissue (p≤ 0.001). The results showed a significant increase in the number of markers of Th17 (RORC2 and IL-17 genes) compared to markers of Th2 (GATA-3, IL-4) in patients with periodontitis compared to controls (p≤0.002). A positive correlation between IL-17 and RORC2 (p≤0.05) and between IL-4 and GATA-3 (p≤0.001) was found. 
  Conclusion: The results show that expression levels of IL-4, GATA-3, IL-17 and RORC2 increase significantly in periodontal lesions compared with the controls. In periodontal lesions, IL-17 levels are significantly greater than IL-4, which plays a protective role against alveolar bone loss.

Source: Journal of Dentistry of Tehran University of Medical Sciences

Full Text

Keywords: TH17 cell;TH2 cell; IL-17F protein; GATA3 factors; Periodontal Disease
     
Type of Study: Research | Subject: Periodontology
Received: 2013/02/18 | Published: 2012/01/15
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Behfarnia P, Birang R, Pishva S S, Ghanjali Hakemi M, Mohammadi Khorasani M. Expression Levels of Th-2 and Th-17 Characteristic Genes in Healthy Tissue Versus Periodontitis. 3 2012; 6 (6)
URL: http://idai.ir/article-1-985-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 6 (1-2012) Back to browse issues page
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

کلیه حقوق سایت متعلق به جامعه اسلامی دندانپزشکان ایران است. تماس با ما

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