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:: دوره 3، شماره 3 - ( مجموعه مقالات بیماری های دهان 1390 ) ::
جلد 3 شماره 3 صفحات 0-0 برگشت به فهرست نسخه ها
Outcomes following chemoradiotherapy for N3 head and neck squamous cell carcinoma without a planned neck dissection
چکیده:   (3464 مشاهده)

 Objectives The optimal management of the N3 neck in head and neck squamous cell carcinoma (HNSCC) remains controversial. We report the outcomes of patients with N3 disease treated with a strategy of concurrent chemo-radiotherapy (CRT)±induction chemotherapy (ICT) without a planned neck dissection.

 Materials and methods Forty patients with HNSCC N3 disease treated between January 2004 and December 2010 were retrospectively identified. Inclusion criteria for the study were: non-nasopharyngeal HNSCC, N3 nodal disease, intention to treat with CRT±ICT.

 Results Median age was 60 (range 39–74). Median follow up was 32months (range 8–88). 34 (85%) of patients received ICT. 35 patients received cisplatin-CRT, 4 carboplatin-CRT and 1 patient was treated with radiotherapy alone due to ICT toxicity. 27 (67.5%) patients had a complete response (CR) to CRT. 5 (12.5%) patients had an incomplete response in both the primary and nodal sites. 8 (20%) patients had a CR in the primary site but incomplete in the nodal regions. The crude rate of regional failure following a CR was 3/27 (11.2%). Isolated regional failure occurred in 1/27 (3.7%) patients who had achieved a CR post-CRT. 3year overall survival, disease free survival, locoregional control, local control and regional control in the whole cohort were 51.4%, 49.6%, 65.7%, 77.3%, 69.3%, and in patients with a CR were 73.3%, 70.0%, 86.6%, 90.5% and 91.7% respectively.

 Conclusion Isolated regional nodal failure is rare following a complete response to CRT for N3 HNSCC managed without a planned neck dissection.


 Source: Journal of Oral Oncology

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نوع مطالعه: پژوهشي | موضوع مقاله: بیماری های دهان
دریافت: 1391/10/5 | انتشار: 1390/10/25
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Karakaya E, Yetmen O, Oksuz D C, E. Dyker K, Coyle C, Sen M et al . Outcomes following chemoradiotherapy for N3 head and neck squamous cell carcinoma without a planned neck dissection. 3 2012; 3 (3)
URL: http://idai.ir/article-1-876-fa.html

Outcomes following chemoradiotherapy for N3 head and neck squamous cell carcinoma without a planned neck dissection. 1. 1390; 3 (3)

URL: http://idai.ir/article-1-876-fa.html



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دوره 3، شماره 3 - ( مجموعه مقالات بیماری های دهان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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