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:: Volume 8, Issue 8 (1-2012) ::
3 2012, 8(8): 0-0 Back to browse issues page
Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients
Joost R van der Vorst , Boudewijn E. Schaafsma , Floris P.R. Verbeek , Stijn Keereweer , Jeroen C. Jansen , Lilly-Ann Van der Velden , Antonius P.M. Langeveld , Cornelis • J.H. van de Velde , John • V. Frangioni , Alexander L. Vahrmeijer *
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Abstract:   (2434 Views)

 Objectives Elective neck dissection is frequently performed during surgery in head and neck cancer patients. The sentinel lymph node (SLN) procedure can prevent the morbidity of a neck dissection and improve lymph node staging by fine pathology. Near-infrared (NIR) fluorescence imaging is a promising technique to identify the sentinel lymph node (SLN) intraoperatively. This feasibility study explored the use of indocyanine green adsorbed to human serum albumin (ICG:HSA) for SLN mapping in head and neck cancer patients.

 Materials and methods A total of 10 consecutive patients with oral cavity or oropharyngeal cancer and a clinical N0 neck were included. After exposure of the neck, 1.6mL of ICG:HSA (500μM) was injected at four quadrants around the tumor. During the neck dissection, levels I–IV were measured for fluorescence using the Mini-FLARE imaging system.

 Results In all 10 patients, NIR fluorescence imaging enabled visualization of one or more SLNs. A total of 17 SLNs were identified. The mean contrast between the fluorescent signal of the lymph nodes and of the surrounding tissue was 8.7±6.4. In 3 patients, of which 1 was false-negative, lymph node metastases were found. After administration of ICG:HSA, the average number of fluorescent lymph nodes significantly increased over time (P<0.001).

 Conclusion This study demonstrated feasibility to detect draining lymph nodes in head and neck cancer patients using NIR fluorescence imaging. However, the fluorescent tracer quickly migrated beyond the SLN to higher tier nodes.


 Source: Journal of Oral Oncology

 Full Text

Keywords: Near-infrared fluorescence, Image-guided surgery, Oral cavity cancer, Oropharynx cancer, Sentinel lymph node, Indocyanine green
     
Type of Study: Research | Subject: Oral and Maxillofacial Surgery
Received: 2012/12/24 | Published: 2012/01/15
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van der Vorst J R, E. Schaafsma B, P.R. Verbeek F, Keereweer S, C. Jansen J, van der Velden L, et al . Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients. 3 2012; 8 (8)
URL: http://idai.ir/article-1-870-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8, Issue 8 (1-2012) Back to browse issues page
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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