Background and aim. The aim of the present study was to evaluate the association of TNFR2 (+587T/G) gene polymorphism with chronic periodontitis (CP).

  Materials and methods. One hundred and seventy four non smoker patients (age 35-72 years) with chronic periodontitis were selected according to established criteria. They were categorized into three groups according to their probing pocket depth (PPD), clinical attachment level (CAL), and alveolar bone loss (ABL). Single nucleotide polymorphism at position +587 (T/G) in the TNFR2 gene was detected by a polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method.

  Results: The distribution of genotypes for TNFR 2 polymorphism at position + 587 was not significantly different amongst moderate and sever chronic periodontitis patients compared with controls (P=0.33). In addition، the frequency of the +587 allele was not associated with the number of teeth (P=0.58) mean PPD (P=0.9), mean CAL (P=0.94) ، mean ABL (P=0.99) and bleeding on probing (BOP) (P=0.07) in the patients studied.

  Conclusion: This study suggests that there is no correlation between genotype and level of severity of chronic periodontitis.

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