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Association of Tumor Necrosis Factor Receptor Type 2 Gene Polymorphism with Severe Chronic Periodontitis
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Masoumeh Khoshhal   , Hengameh Khosro Panah , Mahdi Kadkhodazadeh , Fariborz Vafaee * |
| Hamadan University of Medical Sciences, Hamadan, Iran |
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Abstract: (2418 Views) |
Background and aims. The aim of the present study was to evaluate the association between TNFR2(+587T/G) gene polymorphism and chronic periodontitis (CP). Materials and methods. Results. Conclusion.
Source: Journal of Periodentology & Implant Dentistry Full text This study suggests that there is no correlation between genotype and severity of chronic periodontitis. The distribution of genotypes for TNFR2 polymorphism at position +587 was not significantly different between moderate and severe chronic periodontitis patients compared with controls (P=0.33). In addition, the frequency of the +587 allele was not associated with the number of teeth (P=0.58), mean PPD (P=0.9), mean CAL (P=0.94), mean ABL (P=0.99) and bleeding on probing (BOP) (P=0.07) in the patients studied. One hundred and seventy-four non-smoking patients (35-72 years of age) with chronic periodon-titis were selected according to established criteria and divided into three groups according to their probing pocket depth (PPD), clinical attachment level (CAL), and alveolar bone loss (ABL). Single nucleotide polymorphism at position +587 (T/G) in the TNFR2 gene was detected by a polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) me-thod. |
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| Keywords: Bone loss, chronic periodontitis, cytokine, gene, polymorphism |
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Type of Study: Research |
Subject:
Periodontology
Received: 2012/04/2 | Published: 2012/01/15
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