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Serum level of interleukin 17 in patients with erosive and non erosive oral lichen planus
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چکیده: (1478 مشاهده) |
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Background and aims. Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus.
Materials and methods. This descriptive analytical study included 24 patients with erosive oral lichen planus (EOLP), 24 patients with non-erosive oral lichen planus (NEOLP) and 24 healthy volunteered as control. Blood samples of the subjects underwent ELISA, using special kits, to determine serum interleukin-17 levels. Data was analyzed using with descriptive statistic, chi-square test, and one-way ANOVA and Tukey post-hoc test with SPSS 16 software. Results. EOLP patients showed a high level of serum IL-17 compared with NEOLP patents and control groups (EOLP=184.16 ± 12.41 pg/mL, NEOLP=106.09±10.78 pg/mL, control=15.50 ± 4.34 pg/mL, P - 0.001). Conclusion. High level of serum IL-17 in erosive oral lichen planus patients compared to the non-erosive type and healthy individuals may be the reason for higher inflammation and atrophy in the erosive type.
Source:
Journal of Dental Research, Dental Clinics, Dental Prospects
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| واژههای کلیدی: Oral Lichen Planus، Interleukin-17 |
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نوع مطالعه: پژوهشي |
موضوع مقاله:
بیماری های دهان
دریافت: 1394/6/19 | پذیرش: 1394/6/19 | انتشار: 1394/6/19
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