[صفحه اصلی ]   [Archive] [ English ]  
جستجو در پایگاه

جستجوی پیشرفته
..
نظرسنجی
مطالب کدام بخش سایت بیشتر مورد نیاز شماست؟
پرسش و پاسخ
جشنواره شهید هدایت
کلینیک تخصصی دندانپزشکی
مجله علمی
نمایشگاه کتاب
نمایشگاه مواد و تجهیزات دندانپزشکی
نیازمندیها
   
..
:: جلد 0 - ترمیمی ::
جلد 0 - ترمیمی صفحات 0-0 برگشت به فهرست نسخه ها
Loading of Gentamicin Sulfate into Poly (Lactic-Co-Glycolic Acid) Biodegradable Microspheres
چکیده:   (1530 مشاهده)

 Objective: In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days.

  Methods: In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method. The correct morphology of loaded microspheres was ensured using scanning electron microscopy (SEM). The rate of drug release from polymeric microspheres into the phosphate buffered saline (PBS) solution was measured during a 20-day period using spectroscopy. Data were analyzed using one-way ANOVA.

  Results: SEM micrographs showed that the produced microspheres had smooth and nonporous surfaces and 30-micron diameter. Assessment of the pattern of drug release from the PLGA microspheres loaded with gentamycin revealed a burst release on day six followed by a stable pattern of release until day 20.

  Conclusion: Considering the biocompatibility of PLGA and optimal pattern of drug release, PLGA microspheres loaded with gentamicin can be successfully used for infection control and reduction of microbial count in dental treatments.


Source: Journal of Dental School Shahid Beheshti University of Medical Sciences

Full Text

واژه‌های کلیدی: Antibiotic، Controlled release، Drug release system، Gentamicin، Polylactic co-glycolic acid، Polymer microspheres.
     
نوع مطالعه: پژوهشي | موضوع مقاله: ترمیمی
دریافت: 1394/4/6 | پذیرش: 1394/4/6 | انتشار: 1394/4/6
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:


Loading of Gentamicin Sulfate into Poly (Lactic-Co-Glycolic Acid) Biodegradable Microspheres. 1. 1390;

URL: http://idai.ir/article-1-2983-fa.html



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
جلد 0 - ترمیمی برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

کلیه حقوق سایت متعلق به جامعه اسلامی دندانپزشکان ایران است. تماس با ما

Persian site map - English site map - Created in 0.07 seconds with 37 queries by YEKTAWEB 4710