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.Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity
Eilis Lynch * , Delia S. Brauer , Natalia Karpukhina , David G. Gillam , Robert G. Hill
Abstract:   (11741 Views)
Objective

 Dentin hypersensitivity (DH) is a commonly occurring dental condition, and bioactive glasses (BG) are used in dentifrice formulations for treating DH by forming a surface layer of hydroxycarbonate apatite (HCA) on the tooth, thereby occluding exposed dentinal tubules. Fluoride-containing BG, however, form fluorapatite, which is more stable toward acid attack, and provide a more sustainable option for treating DH.

Methods

 Melt-derived multi-component BG (SiO 2 –P 2 O 5 –CaO–CaF 2 –SrO–SrF 2 –ZnO–Na 2 O–K 2 O) with increasing CaF 2 +SrF 2 content (0–32.7AWT IMAGEmol%) were prepared. Apatite formation, occlusion of dentinal tubules in dentin discs and ion release in Tris buffer were characterized in vitro over up to 7 days using X-ray diffraction, infrared spectroscopy, scanning electron microscopy and inductively coupled plasma emission spectroscopy.

Results

 The fluoride-containing bioactive glasses formed apatite from as early as 6AWT IMAGEh, while the fluoride-free control did not form apatite within 7 days. The glasses successfully occluded dentinal tubules by formation of apatite crystals and released ions such as fluoride, strontium and potassium.

Significance

 Fluoride significantly improved apatite formation of the BG, allowing for treatment of DH by occlusion of dentinal tubules. The BG also released therapeutically active ions, such as strontium and fluoride for caries prevention, zinc for bactericidal properties and potassium, which is used as a desensitizing agent in dentifrices.


  Source: Dental Materials

  Full text

Keywords: Dentin hypersensitivity, Bioactive glass, Fluoride, Fluorine, Apatite, Fluorapatite, Dentinal tubules, Strontium, Potassium, Zinc
     
Type of Study: Research | Subject: Cosmetic and Restorative Dentistry
Received: 2012/02/9 | Accepted: 2015/12/16 | Published: 2015/12/16
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Lynch E, S. Brauer D, Karpukhina N, G. Gillam D, G. Hill R. .Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity. 3 2012;
URL: http://idai.ir/article-1-273-en.html


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جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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