DNA Damage in Oral Mucosa Cells of Patients with Fixed Orthodontic Appliances
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چکیده: (1536 مشاهده) |
Objective: The release of toxic metal ions from orthodontic alloys has induced concerns regarding the biocompatibility of fixed appliances. This study investigated the genotoxic effect of metal appliances in a sample of patients undergoing fixed orthodontic treatment. Materials and Methods: The study included twenty-five healthy individuals requiring orthodontic therapy in both jaws. The patients were treated by stainless steel orthodontic brackets and nickel-titanium or stainless steel arch wires. The oral mucosa cells were gathered just before the appliance placement and 9 months later. The cells were centrifuged, fixed and dropped onto slides. After staining, the micronucleus (MN) assay was used to determine genome alteration. The data were analyzed by paired sample t-test. Results: The mean micronuclei frequency in the buccal mucosa was 10.6 ± 5.7 per 1000 cells before the appliance placement and 9.2 ± 6.37 per 1000 cells 9 months later. No significant difference was found in the MN count before and 9 months after therapy (p=0.336). Conclusion: Under the conditions used in this study, application of fixed orthodontic appliances did not expose healthy individuals to increased risk of DNA damage in oral mucosa cells.
Source: Journal of Dentistry of Tehran University of Medical Science Full Text |
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واژههای کلیدی: Orthodontic Appliances; DNA Damage; Micronucleus Test; Biocompatibility; Genotoxicity |
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نوع مطالعه: پژوهشي |
موضوع مقاله:
ارتودنسی دریافت: 1392/9/23 | پذیرش: 1392/9/23 | انتشار: 1392/9/23
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