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:: دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) ::
جلد 1 شماره 1 و 1 صفحات 0-0 برگشت به فهرست نسخه ها
DNA Damage in Oral Mucosa Cells of Patients with Fixed Orthodontic Appliances
چکیده:   (1536 مشاهده)

 Objective:

  The release of toxic metal ions from orthodontic alloys has induced concerns regarding the biocompatibility of fixed appliances. This study investigated the genotoxic effect of metal appliances in a sample of patients undergoing fixed orthodontic treatment.

 Materials and Methods:

  The study included twenty-five healthy individuals requiring orthodontic therapy in both jaws. The patients were treated by stainless steel orthodontic brackets and nickel-titanium or stainless steel arch wires. The oral mucosa cells were gathered just before the appliance placement and 9 months later. The cells were centrifuged, fixed and dropped onto slides. After staining, the micronucleus (MN) assay was used to determine genome alteration. The data were analyzed by paired sample t-test.

 Results:

  The mean micronuclei frequency in the buccal mucosa was 10.6 ± 5.7 per 1000 cells before the appliance placement and 9.2 ± 6.37 per 1000 cells 9 months later. No significant difference was found in the MN count before and 9 months after therapy (p=0.336).

  Conclusion:

 Under the conditions used in this study, application of fixed orthodontic appliances did not expose healthy individuals to increased risk of DNA damage in oral mucosa cells.


 Source: Journal of Dentistry of Tehran University of Medical Science

 Full Text

واژه‌های کلیدی: Orthodontic Appliances; DNA Damage; Micronucleus Test; Biocompatibility; Genotoxicity
     
نوع مطالعه: پژوهشي | موضوع مقاله: ارتودنسی
دریافت: 1392/9/23 | پذیرش: 1392/9/23 | انتشار: 1392/9/23
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DNA Damage in Oral Mucosa Cells of Patients with Fixed Orthodontic Appliances. 1. 1390; 1 (1 و 1)

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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 1، شماره 1 و 1 - ( مجموعه مقالات ارتودنسی 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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