Objective This study aimed to assess NanoBone as a carrier construct for mesenchymal stem cells (MSCs) and platelet-rich growth factor (PRGF). Study Design In the calvarial bone of 8 mature New Zealand White male rabbits, four 8-mm defects were created. Each defect received one of the following treatments: Group 1, 0.2 mg Nano-hydroxyapatite (HA) granule + 2 mL culture medium Group 2, 0.2 mg Nano-HA + 1 mL autologous PRGF + 2 mL acellular culture medium Group 3, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs Group 4, 0.2 mg Nano-HA + 2 mL culture medium containing 100,000 autogenous MSCs + 1 mL autologous PRGF. Result Histomorphometric analysis at 6 and 12 weeks demonstrated significantly higher bone formation in group 4 (29.45% and 44.55%, respectively) (P < .05). Bone formation in groups 1, 2, and 3 were as follows: 11.35% and 32.53%, 29.10% and 39.74%, and 25.82% and 39.11%, respectively. Conclusions NanoBone with MSCs and PRGF seems to be an effective combination for bone regeneration in a rabbit calvaria model.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Full Text |
