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:: Volume 6, Issue 6 (1-2012) ::
3 2012, 6(6): 0-0 Back to browse issues page
Serum Levels of Long-Chain Polyunsaturated Fatty Acids in Patients With Periodontal Disease
Carlos Marcelo Figueredo * , Gisele L. Martinez , Josely C. Koury , Ricardo G. Fischer , Anders Gustafsson
Faculty of Odontology, Department of Periodontology, Rio de Janeiro State University, Rio de Janeiro, Brazil/Division of Periodontology, Institute of Odontology, Karolinska Institute, Stockholm, Sweden
Abstract:   (1893 Views)

 Background: Long-chain polyunsaturated fatty acids omega-3 and omega-6 (LC-PUFA n-3 and n-6) can function as important inflammatory modulators and also have a strong effect in the proresolving inflammatory processes. The aim of the authors is to analyze the serum levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and arachidonic acid (AA) in patients with generalized chronic periodontitis (GCP) and compare these results with serum levels of patients with gingivitis only.

 Methods: Twenty-one patients with untreated GCP (mean age: 46.0 ± 8.8 years) and 16 patients with gingivitis only (mean age: 31.5 ± 7.5 years) were investigated. The clinical examination included probing depth (PD), clinical attachment level, bleeding on probing, and plaque index. Blood samples were analyzed for the presence of DHA, EPA, DPA, and AA using gas chromatography.

 Results: Significantly higher levels of DHA, DPA, EPA, and AA were observed in patients with GCP when compared with patients with gingivitis (P = 0.007, P = 0.004, P = 0.033, and P = 0.001, respectively). The differences were still significant even after the adjustments for age and sex. The PD showed a significant positive correlation with DHA (r = 0.5 P = 0.003), DPA (r = 0.6 P <0.001), and AA (r = 0.6 P <0.001).

 Conclusion: The present findings suggest that serum levels of LC-PUFA n-3 and n-6 may be affected by the severity of periodontal disease.


 Source: Journal of Periodentology

 Full Text

Keywords: Arachidonic acid, docosahexaenoic acids, eicosapentaenoic acid, inflammation mediators, periodontal diseases, unsaturated fatty acids
     
Type of Study: Research | Subject: Periodontology
Received: 2013/07/14 | Published: 2012/01/15
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Figueredo C M, L. Martinez G, C. Koury J, G. Fischer R, Gustafsson A. Serum Levels of Long-Chain Polyunsaturated Fatty Acids in Patients With Periodontal Disease. 3 2012; 6 (6)
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Volume 6, Issue 6 (1-2012) Back to browse issues page
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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