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:: دوره 6، شماره 6 - ( پریودنتولوژی 1390 ) ::
جلد 6 شماره 6 صفحات 0-0 برگشت به فهرست نسخه ها
Guided Bone Regeneration Using Injectable Vascular Endothelial Growth Factor Delivery Gel
چکیده:   (2019 مشاهده)

 Background: Vascularization underlies the success of guided bone regeneration (GBR) procedures. This study evaluates the regenerative potential of GBR in combination with vascular endothelial growth factor (VEGF) delivery via an injectable hydrogel system.

 Methods: Critical-sized defects were created in rat calvariae, and GBR procedures were performed with a collagen membrane alone (control), or plus bolus delivery of VEGF, or plus application of VEGF-releasing hydrogels (VEGF–Alg). Four and 8 weeks after treatment, defect sites were evaluated with microcomputed tomographic and histomorphometric analyses for blood vessel and bone formation.

 Results: At 4 weeks, relative to the control condition, the bolus addition of VEGF did not affect blood vessel density within the defect site, yet the application of VEGF–Alg significantly (P <0.05) increased blood vessel density. Although there was no difference in bone regeneration at 4 weeks, at 8 weeks there was a significant (P <0.05) increase in bone regeneration in the VEGF–Alg-treated defects.

 Conclusions: These data demonstrate that the application of VEGF–Alg enhanced early angiogenesis, whereas at a later time point, it enhanced bone regeneration. Controlled delivery approaches of angiogenic growth factors used adjunctively with GBR may be a promising strategy for enhancing outcomes of GBR.


 Source: Journal of Periodentology

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نوع مطالعه: پژوهشي | موضوع مقاله: پریودنتولوژی
دریافت: 1392/4/19 | انتشار: 1390/10/25
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Kaigler D, A. Silva E, J. Mooney D. Guided Bone Regeneration Using Injectable Vascular Endothelial Growth Factor Delivery Gel. 3 2012; 6 (6)
URL: http://idai.ir/article-1-1276-fa.html

Guided Bone Regeneration Using Injectable Vascular Endothelial Growth Factor Delivery Gel. 1. 1390; 6 (6)

URL: http://idai.ir/article-1-1276-fa.html



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 6، شماره 6 - ( پریودنتولوژی 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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