[Home ] [Archive]   [ فارسی ]  
Search in website

Advanced Search
..
:: Volume 6, Issue 6 (1-2012) ::
3 2012, 6(6): 0-0 Back to browse issues page
Effectiveness of Adjunctive Subantimicrobial Dose Doxycycline on Phase I of Periodontal Therapy
Ahmad Haerian , Farzaneh Vaziri * , Fazele AttarbashiMoghadam , Davoud Zare , Fahimeh RashidiMeibodi , Mina Ayatollahi
Department of Periodontics, Shahid Sadughi University of Medical Sciences, Yazd, Iran
Abstract:   (3072 Views)

 Background and aims. Periodontal disease is a complex interaction between bacteria and susceptible host. MMPs has a key role in periodontal disease and increase with disease severity which cause destruction of extra cellular matrix in chronic periodontitis. HMT is a therapeutic hypothesis which its objection is the reduction of tissue destrucion. Doxycyclines can inhibit MMPs activation through the synthesis of intracellular enzymes. The objective of this study was to evaluate the Effectiveness of adjunctive Subantimicrobial Dose Doxycycline on phase I of periodontal therapy.

 Materials and methods. Forty patients with chronic periodontitis were included in this randomized double blind placebo control parallel group clinical study. After scaling and root planning patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3 months and were evaluate in 3month and 6 month later.

 Results. Clinical parameter improved significantly in both groups (p-value˂0.0001). Significant reduction in PD, CAL and BOP was seen in SRP +SDD group compare to control group (p-value˂0.0001).

 Conclusion. Short administration of SDD gives significant benefit in clinical parameters in chronic periodontitis.


 Source: Journal of Periodentology & Implant Dentistry

 Full Text

Keywords: SDD, clinical parameters, chronic periodontitis, host modulation therapy
     
Type of Study: Research | Subject: Periodontology
Received: 2013/07/8 | Published: 2012/01/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haerian A, Vaziri F, AttarbashiMoghadam F, Zare D, RashidiMeibodi F, Ayatollahi M. Effectiveness of Adjunctive Subantimicrobial Dose Doxycycline on Phase I of Periodontal Therapy. 3 2012; 6 (6)
URL: http://idai.ir/article-1-1234-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 6, Issue 6 (1-2012) Back to browse issues page
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

کلیه حقوق سایت متعلق به جامعه اسلامی دندانپزشکان ایران است. تماس با ما

Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4710