Department of Oral Medicine, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (2468 Views)
Background and aims.
Biocompatibility of root-end filling materials is a matter of debate. The aim of this study was to compare the biocompatibility of a variety of commercial ProRoot WMTA cements and a resin-based cement (Geristore®) with different pH values of setting reaction and different aluminum contents, implanted into the subcutaneous connective tissue of rats at various time intervals.
Materials and methods.
Fifty Sprague-Dawley rats were used in this study. Polyethylene tubes were filled with Angelus WMTA, ProRoot WMTA, Bioaggregate, and Geristore. Empty control tubes were implanted into subcutaneous tissues and harvested at 7-, 14-, 28- and 60-day intervals. Tissue sections of 5 μm were stained with hematoxylin and eosin and observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells) 1, mild (inflammatory cells ≤25) 2, moderate (25–125 inflammatory cells) and 3, severe (>125 inflammatory cells). Statistical analysis was performed with Kruskal-Wallis and Mann Whitney U tests.
Results.
ProRoot WMTA and Angelus elicited significantly less inflammation than other materials (P< 0.05). After 7 days, however, all the materials induced significantly more inflammation than the controls (P< 0.05). Angelus-MTA group exhibited no significant differences from the Bioaggregate group (P=0.15) however, ProRoot WMTA elicited significantly less inflammation than Bioaggregate (P=0.02). Geristore induced significantly more inflammation than other groups (P< 0.05).
Conclusion.
Geristore induced an inflammatory response higher than ProRoot WMTA therefore, it is not recommended for clinical use.
Source: Journal of Dental Research, Dental Clinics, Dental Prospects
Saghiri M A, Tanideh N, Garcia-Godoy F, Lotfi M, Karamifar K, Amanat D. Subcutaneous connective tissue reactions to various endodontic biomaterials: an animal study. 3 2012; 3 (3) URL: http://idai.ir/article-1-1075-en.html