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:: دوره 11، شماره 11 - ( کودکان 1390 ) ::
جلد 11 شماره 11 صفحات 0-0 برگشت به فهرست نسخه ها
Simvastatin versus calcium hydroxide direct pulp capping of human primary molars: a randomized clinical trial
چکیده:   (1995 مشاهده)

 Background and aims.

  The aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (DPC) with calcium hydroxide [Ca(OH)2] and simvastatin as pulp-capping materials in the primary human molars.

 Materials and methods.

  120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. Group Ι as a control, underwent DPC with calcium hydroxide. The dental pulp in group ІІ, ІІІ and ІV were directly capped with simvastatin-based materials at concentrations of 1, 5 and 10 µM, respectively. All of the teeth were restored with stainless steel crown. After a mean period of 7.41 months teeth were extracted and processed for histological examination and categorized in terms of hard tissue formation and pulp inflammation.

 Results.

  Teeth in group I had statistically favorable outcomes in hard tissue formation and pulp inflammation than did the groups ІІ, ІІІ and ІV (P < 0.001). Considering three different concentrations of simvastatin, the result showed a dose dependent trend. Teeth in group ІV showed significantly lower rates of hard tissue formation and higher rates of pulp inflammation and necrosis compared to those of groups ІІ (P < 0.05).

 Conclusion.

  The findings of this study depicted that healing with no inflammation and hard tissue formation following statin treatment occurs with a lower rate than that with the calcium hydroxide.  


 Source: Journal of Dental Research, Dental Clinics, Dental Prospects

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نوع مطالعه: پژوهشي | موضوع مقاله: کودکان
دریافت: 1392/2/22 | انتشار: 1390/10/25
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Asl Aminabadi N, Maljaei E, Erfanparast L, Ala Eghbali A, Hmaishehkar H, najafpour E. Simvastatin versus calcium hydroxide direct pulp capping of human primary molars: a randomized clinical trial. 3 2012; 11 (11)
URL: http://idai.ir/article-1-1074-fa.html

Simvastatin versus calcium hydroxide direct pulp capping of human primary molars: a randomized clinical trial. 1. 1390; 11 (11)

URL: http://idai.ir/article-1-1074-fa.html



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Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 11، شماره 11 - ( کودکان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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