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جشنواره سال 1392: نفرات برتر مقاله پژوهشی آسیب شناسی دهان و فک

 نفرات برتر  مقاله پژوهشی آسیب شناسی دهان و فک

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 نفر اول مقاله پژوهشی آسیب شناسی دهان و فک

 The expression of heat shock proteins 27 and 105 in squamous cell carcinoma of the tongue and relationship with clinicopathological index

 


  Nooshin Mohtasham , Shahab Babakoohi *, Laleh Montaser-Kouhsari , Bahram Memar , Jahanshah Salehinejad , Amin Rahpeyma , Saeedeh Khageh-Ahmady , Parviz Marouzi , Alireza Firooz , Hamidreza Pazoki-Toroudi , Kazem Anvari

  * MD, PhD Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran

 

  Abstract

  Introduction: In oral cavity, the tongue is the most common site prone to development of squamous cell carcinoma (SCC). Considering malignant transformation as a cellular stress, the expression of heat shock proteins (HSPs) may be affected in this process. In this study we assessed the expression of HSP105 and HSP27 as two of the most interested stress proteins and investigated their relationship with grade and stage of the tongue SCC.

  Material and Methods: Fifty-six specimens including 31 early and 25 advanced tongue SCC were gathered. All specimens were graded histologically from I to III. Sixteen sections of normal oral mucosa were used as control group. The cellularity and intensity of HSP105 and HSP27 expression were studied immunohistochemically in both case and control groups. Results were expressed by histochemical score (HSCORE).

  Results: Significant differences were observed between expression of HSPs and stage of the disease. From early to advanced stage, the expression of HSP105 and HSP27 increased and decreased, respectively. There was no relationship between histological grade of lesion and HSCORE of HSP105 expression (P=0.5), although, HSP27 expression had reverse relationship with the SCC histological grade.

  Conclusion: HSP27 and HSP105 may be indicated for prognostic purposes in evaluation of tongue SCC. HSP 27 may be used for more accurate microscopic grading of tongue SCC. Increased expression of HSP105 in advanced stage may lead to using this protein for immunotherapy of tongue SCC.

  Key words: Heat shock protein 27 , Heat shock protein 105 , tongue squamous cell carcinoma.


  Med Oral Patol Oral Cir Bucal. 2011 Sep 1;16 (6):e730-5

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نفر دوم مقاله پژوهشی آسیب شناسی دهان و فک

Treatment of oral squamous cell carcinoma using anti-HER2 immunonanoshells


   Reza Fekrazad , Neda Hakimiha , Enice Farokhi , Mohammad Javad Rasaee , Mehdi Shafiee Ardestani, Katayoun AM Kalhori , Farzaneh Sheikholeslami


  International Journal of Nanomedicine 2011:6 2749–2755

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