Statement of Problems: An ideal antimicrobial agent should have minimal cytotoxic effect to host cells. Purpose: The aim of this study was to determine the cytotoxic effect of three commercial mouthwashes (Chlorhexidine, Persica and Irsha) on the cultured fibroblasts.

  Material and Methods: For determining the cytotoxic effect of Irsha, Chlorhexidine and Persica, uninfected cells were grown in the absence and presence of various concentration (2,4,8,16,32,64,128) of these mouth washes for 1, 2, 3 and 4 days.

 Results: In this study, three mouth washes show cytotoxic effect on the cultured cells, at commercially available concentration and even diluted and Irsha was found to be the most toxic one. Cytotoxicity of three mouthwashes was reduced with decreasing concentration.

 Conclusion: Our results showed that all three solutions were toxic to the cultured fibroblast. Other studies which investigate their clinical effect are recommended.

 Source: Journal of Dentistry Shiraz University of Medical Sciences

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