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:: دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) ::
جلد 4 شماره 4 صفحات 0-0 برگشت به فهرست نسخه ها
A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws
چکیده:   (8738 مشاهده)
Objective

 The objective of this study was to assess whether a minimally invasive protocol can be effective in the long-term control of necrotic areas and pain in patients suffering osteonecrosis of the jaw associated with the use of bisphosphonate drugs (BRONJ).

Study design

 Thirty-four consecutive patients (14 male, 20 female) with BRONJ under treatment with zoledronate, pamidronate, or alendronate were enrolled. All of the patients received professional oral hygiene treatment and antiseptic oral rinses, and if in pain they assumed an antibiotic therapy with amoxicillin/clavulanate potassium and metronidazole for ten days. At the baseline visit, as well as at each 3-month recall, the size of the osteonecrotic lesions were measured and the pain level assessed with a visual analog scale.

Results

 The results from the general linear model showed a statistically significant (F = 16.1 P < .01 r2 = 0.95) time-related decrease in the size of exposed bone areas during the nonsurgical therapy (from 12.5 ± 12.0 mm to 8.8 ± 10.3 mm).

Conclusions

 This conservative protocol seems to provide successful treatment in the vast majority of patients.


  Source: Journal of oral surgery, oral Medicine, Oral Pathology

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نوع مطالعه: پژوهشي | موضوع مقاله: پاتولوزی دهان، فک و صورت
دریافت: 1391/2/13 | انتشار: 1390/10/25
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Moretti F, Peliccioni G A, Montebugnoli L, Marchetti C. A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws. 3 2012; 4 (4)
URL: http://idai.ir/article-1-481-fa.html

A prospective clinical trial for assessing the efficacy of a minimally invasive protocol in patients with bisphosphonate-associated osteonecrosis of the jaws. 1. 1390; 4 (4)

URL: http://idai.ir/article-1-481-fa.html



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دوره 4، شماره 4 - ( مجموعه مقالات پاتولوژی فک و دهان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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