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Incidence assessment of MTHFR C677T and A1298C polymorphisms in Iranian non-syndromic cleft lip and/or palate patients
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چکیده: (1593 مشاهده) |
Background and aims. The aim of the present study is to determine the incidence of MTHFR C677 T and A1298C mutations in Iranian patients with cleft lip and/or cleft palate. Materials and methods. We screened 61 Iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of MTHFR gene associated with cleft lip and/or palate: A1298C and C677T, using Polymerase Chain Reaction following by RFLP. Results. The 677T and 1298C homozygote genotypes showed a frequency of 36.1% and 11.4%, respectively. Combined genotype frequencies in newborns having oral clefts showed that the highest genotype was 677TT/1298AA (22.9%) and 677TT/1298CC genotypes were not observed. Conclusion. The results showed that 65.6% of all patients had at least one T mutant allele in C677T and 58.9% C mutant allele for A1298C. According to the frequencies of homozygosity of mutant alleles, it could be said that MTHFR genotype of 677TT shows a greater role in having oral clefts.
Source:
Journal of Dental Research, Dental Clinics, Dental Prospects
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| واژههای کلیدی: A1298C، C677T، methylenetetrahydrofolate reductase، orofacial cleft، polymorphism |
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نوع مطالعه: پژوهشي |
موضوع مقاله:
کودکان
دریافت: 1394/6/22 | پذیرش: 1394/6/22 | انتشار: 1394/6/22
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