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:: دوره 11، شماره 11 - ( کودکان 1390 ) ::
جلد 11 شماره 11 صفحات 0-0 برگشت به فهرست نسخه ها
In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine
چکیده:   (1685 مشاهده)

 Objectives

 To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with the RMGIC applied on remaining dentine after indirect pulp treatment (IPT).

  Methods

  For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months.

 Results

  The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT.

 Conclusion

  The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT.


 Source: Journal of Dentistry

 Full Text

واژه‌های کلیدی: Glass ionomer cement، Chlorhexidine digluconate، Cell culture، Antibacterial activity، Mechanical properties، Indirect pulp therapy
     
نوع مطالعه: پژوهشي | موضوع مقاله: کودکان
دریافت: 1392/7/11 | انتشار: 1390/10/25
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In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine. 1. 1390; 11 (11)

URL: http://idai.ir/article-1-2133-fa.html



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 11، شماره 11 - ( کودکان 1390 ) برگشت به فهرست نسخه ها
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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