en بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Purpose</strong> To investigate the intraepithelial microvascular morphology of oral squamous cell carcinoma (OSCC) by using narrow-band imaging (NBI) and analyze whether the intraepithelial papillary capillary loop (IPCL) patterns correlate with infiltration depth and disease severity in OSCC. </p><p> <strong>Methods</strong> The clinicopathologic data, morphology of vascular architecture as observed by NBI, and histopathology of patients with OSCC were retrospectively reviewed and analyzed. </p><p><strong>Results</strong> A total of 80 patients, including 73 males and 7 females with an average age of 54.18±12.23years, were enrolled. Three patterns of intraepithelial microvasculature were revealed by NBI and differences in these three patterns were significant with regard to pathologic T-classification (p<0.0001), N-classification (p=0.00022), TNM stage (p<0.0001), lymphovascular invasion (p<0.0001), perineural invasion (p=0.000299), depth of tumor infiltration (p<0.0001), and tumor differentiation (p<0.0001). A cut-off point of tumor infiltration of 10.012mm was best predicted for the destructive pattern of IPCL (sensitivity=100%, specificity=90.0%). </p><p> <strong>Conclusions</strong> Three different patterns of IPCL, showing step-wise increased severity according to pathologic parameters, were observed by NBI in cases of OSCC. The pattern indicating IPCL destruction with angiogenesis was associated with more advanced disease stage.</p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Oncology </p><p><a href="http://www.oraloncology.com/article/S1368-8375(12)00227-8/abstract" target="_blank"><font color="#0033ff"> Full Text</font></a> </p><p></p> Oral squamous cell carcinoma, Narrow-band imaging, Invasion depth, Intraepithelial papillary capillary loop, Endoscopy 0 0 http://idai.ir/browse.php?a_code=A-10-32-861&slc_lang=en&sid=1 Shih-Wei Yang 10031947532846003766 10031947532846003766 Yes Department of Otolaryngology – Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC Yun-Shien Lee 10031947532846003767 10031947532846003767 No Department of Biotechnology, Ming Chuan University, Taoyuan, Taiwan, ROC Liang-Che Chang 10031947532846003768 10031947532846003768 No Department of Pathology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC Tsan-Yu Hsieh 10031947532846003769 10031947532846003769 No Department of Pathology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC Tai-An Chen 10031947532846003770 10031947532846003770 No Department of Otolaryngology – Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC