en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <br><strong>Abstract <br></strong><p>  <strong>Background: </strong>Solid ameloblastoma (SAB) is an invasive tumor which infiltrates adjacent normal tissues. Adenomatoid odontogenic tumor is a noninvasive tumor and never infiltrates surrounding normal tissues. The purpose of this study was to determine the biological behavior of these two epithelial odontogenic neoplasm by detecting Ki-67 and Bcl-2, which are mitotic and anti apoptotic markers respectively.</p><p>  <strong>Materials and Methods: </strong>In this analytical retrospective study, 16 samples of SAB and 16 samples of adenomatoid odontogenic tumor were selected. The samples were deparafinized and antigens were retrieved. Immunohistochemistry technique was applied for evaluation of these two markers. Monoclonal antibodies MIB1 and Bcl-2 were used to detect Ki-67 and Bcl-2 protein respectively, then the labeling index (LI) was calculated for both markers according to cellular staining. Data were analyzed by “<i>t</i>” test, (<i>P<</i>0.05).</p><p>  <strong>Results: </strong>The mean values of LI for Ki-67 in SAB and Adenomatiod odontogenic tumor (AOT) were 4 and 1% respectively and for Bcl-2 in SAB and AOT were 63 and 26% respectively. The indices of both markers were higher in SAB compared to AOT (<i>P<</i>0.05).</p><p>  <strong>Conclusions: </strong>Higher percentage of these two markers in SAB compared to AOT confirms the aggressive behavior of SAB and the hamartomatosis behavior of AOT. </p><hr><p></p><p> <strong> Source: </strong>Dental Research Journal </p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/965"><font color="#0000cc">  Full text</font></a> </p> Adenomatoid odontogenic tumor, ameloblastoma, Bcl-2 protein, immunohistochemistry, Ki-67 antigene 0 0 http://idai.ir/browse.php?a_code=A-10-32-446&slc_lang=en&sid=1 Seyed Mohammad Razavi 10031947532846001825 10031947532846001825 No Isfahan University of Medical Sciences, Isfahan, Iran Seyed Hossein Tabatabaie 10031947532846001826 10031947532846001826 No Yazd Dental School, Shahid Sadughi University, Yazd, Iran Ali Tvakoli Hosseini tavakoli21@yahoo.com 10031947532846001827 10031947532846001827 Yes Isfahan University of Medical Sciences, Isfahan, Iran Ehsan Tvakoli Hosseini 10031947532846001828 10031947532846001828 No Yazd Dental School, Shahid Sadughi University, Yazd, Iran Arezo Khabazian 10031947532846001829 10031947532846001829 No Shahid Beheshti University, Tehran, Iran