en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <div class="para"><p><b>Background: </b> Amyloidosis is associated with or caused by amyloid deposition. These fibrillar proteins may be deposited extracellularly causing tissue damage or impairment.</p></div><div class="para"><p><b>Objectives: </b> The aim of the study was to retrospectively review pathology archives in two oral diagnostic centers for cases fulfilling criteria of amyloidosis and to differentiate AA and AL types of amyloidosis.</p></div><div class="para"><p><b>Methods: </b> The clinicopathological features, alkaline Congo red staining, with and without pretreatment with potassium permanganate, and immunohistochemical (IHC) staining with anti-AA, anti-kappa (κ), and anti-lambda (λ) light chain antibodies were carried out and analyzed.</p></div><div class="para"><p><b>Results: </b> The search identified 14 cases. Ten patients were women and four were men, with a mean age of 58 years. Eleven patients had systemic involvement by amyloidosis (associated either with multiple myeloma or plasma cell dyscrasia/monoclonal gammopathies), while three presented the localized type, one of them associated with plasmacytoma. All cases showed positivity for κ or λ light chains (AL-amyloid) and presented resistance to the potassium permanganate pretreatment.</p></div><div class="para"><p><b>Conclusions: </b> Our results show that the head and neck region is preferentially affected by systemic AL-amyloidosis, usually associated with plasma cell dyscrasia. Interestingly, two cases affected by inflammatory rheumatic diseases presented AL-amyloid deposition. Moreover, even after pretreatment with potassium permanganate, which was helpful in highlighting the presence of AL-amyloid, in agreement with the IHC findings, clinical classifications should be carefully made in systemic amyloidosis.</p><p><hr></p><font size="3"><p dir="ltr"><strong>Source:</strong> Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01073.x/abstract" target="_blank"><font color="#0000cc">Full text</font></a></p></font></div> AA,Al,amyloidosis,clinicopathological features,head and neck 0 0 http://idai.ir/browse.php?a_code=A-10-32-312&slc_lang=en&sid=1 Adriele Ferreira Gouvêa Gouvêa 10031947532846001312 10031947532846001312 Yes Ana Carolina Prado Ribeiro 10031947532846001313 10031947532846001313 No Jorge Esquiche León 10031947532846001314 10031947532846001314 No Román Carlos 10031947532846001315 10031947532846001315 No Oslei Paes de Almeida 10031947532846001316 10031947532846001316 No Márcio Ajudarte Lopes 10031947532846001317 10031947532846001317 No