fa Randomized Controlled Trial: A Randomized Controlled Clinical Trial Comparing A Remineralizing Paste with an Antibacterial Gel to Prevent Early Childhood Caries کودکان Pediatric Dentistry پژوهشي Research <p> <strong>Purpose:</strong></p><p>  The purpose of this study was to compare twice daily tooth-brushing using 0.304 percent fluoride toothpaste alone with: (1) twice daily tooth-brushing plus once daily 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste and (2) twice daily tooth-brushing plus once daily 0.12% chlorhexidine gel (CHX) for reducing early childhood caries (ECC) and mutans streptococci (MS) colonization. <strong></strong></p><p> <strong>Methods:</strong></p><p>  Subjects (n=622) recruited at birth were randomized to receive either CPP-ACP or CHX or no product (study control [SC]). All children were examined at 6, 12, and 18 months old in their homes, and at 24 months old in a community dental clinic. </p><p> <strong>Results:</strong></p><p>  At 24 months old, the caries incidence was 1% (2/163) in CPP-ACP, 2% (4/180) in CHX, and 2% (3/188) in SC groups. In children who were previously MS colonized at 12 and 18 months old, 0% (0/11) and 5% (3/63), respectively, of the CPP-ACP group remained MS-positive versus 22% (2/9) and 72% (18/25) in CHX and 16% (4/25) and 50% (7/14) in SC groups (P<.001). </p><p> <strong>Conclusions:</strong></p><p>  There is insufficient evidence to justify the daily use of casein phosphopeptide-amorphous calcium phosphate or chlorhexidine gel to control early childhood caries. </p><hr><p></p><p> <strong>Source: </strong>Journal of American Academy of ‍ Pediatric Dentistry</p><p> <a href="http://www.ingentaconnect.com/content/aapd/pd/2013/00000035/00000001/art00016" target="_blank"><font color="#0000ff">Full Text</font></a></p> CASEIN PHOSPHOPEPTIDE AMORPHOUS CALCIUM PHOSPHATE; CHLORHEXIDINE; DENTAL CARIES; LACTOBACILLUS; STREPTOCOCCUS MUTANS 0 0 http://idai.ir/browse.php?a_code=A-10-32-2514&slc_lang=fa&sid=1 K.A. Plonka 100319475328460011956 100319475328460011956 Yes Center for Pediatric Dentistry, The University of Queensland, Brisbane, Queensland, Australia M.L. Pukallus 100319475328460011957 100319475328460011957 No Center for Pediatric Dentistry, The University of Queensland, Brisbane, Queensland, Australia T.F. Holcombe 100319475328460011958 100319475328460011958 No Center for Pediatric Dentistry, The University of Queensland, Brisbane, Queensland, Australia A.G. Barnett 100319475328460011959 100319475328460011959 No Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia L.J. Walsh 100319475328460011960 100319475328460011960 No School of Dentistry, The University of Queensland, Brisbane, Queensland, Australia W.K. Seow 100319475328460011961 100319475328460011961 No Center for Pediatric Dentistry, The University of Queensland, Brisbane, Queensland, Australia