fa Combined oral midazolam–ketamine better than midazolam alone for sedation of young children: a randomized controlled trial کودکان Pediatric Dentistry پژوهشي Research <p> <strong>Background. </strong></p><p>  There is a lack of clinical trials on paediatric dental sedation. </p><p> <strong>Aim.</strong></p><p>   We investigated whether young children’s behaviour improves during dental treatment with oral ketamine/midazolam compared with midazolam alone or no sedation. </p><p> <strong>Design.</strong> </p><p>  Healthy children under 36 months of age, presenting early childhood caries were randomly assigned to receive protective stabilization plus: combined oral midazolam (0.5 mg/kg) and ketamine (3 mg/kg) (MK), or oral midazolam (1.0 mg/kg) (MS), or no sedative (PS). One observer scored children’s behaviour using the Ohio State University Behavior Rating Scale (OSUBRS) at determined points in a dental exam (no sedative) and treatment session. Data were analysed using nonparametric bivariate tests. </p><p> <strong>Results.</strong> </p><p>  Forty-one children were included. In the dental exam session, the sum of OSUBRS scores was similar for the three groups (P = 0.81). In the treatment session, the MK produced more cooperative behaviour than MS and PS (P = 0.01), longer sessions (P = 0.04), and a pattern of homogeneous OSUBRS scores from the reception area (before sedative administration) to the end of the session (P = 0.06). No immediate and post-discharge side effects were observed in groups MK and MS. </p><p> <strong>Conclusions.</strong> </p><p>  The combination of oral midazolam and ketamine is efficacious for guiding the behaviour of children under 3 years old. </p><hr><p></p><p> <strong>Source: </strong>International Journal of ‍ Pediatric Dentistry</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-263X.2012.01246.x/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-2477&slc_lang=fa&sid=1 THIAGO ANDERSON MOREIRA 100319475328460011801 100319475328460011801 No Division of Anaesthesiology, Federal University of Goiás (UFG), Goiânia, Goiás, Brazil PAULO SUCASAS COSTA 100319475328460011802 100319475328460011802 No Department of Paediatrics, Faculty of Medicine, UFG, Goiania, Goias, Brazil LUCIANE REZENDE COSTA lsucasas@odonto.ufg.br 100319475328460011803 100319475328460011803 Yes Department of Paediatric Dentistry, Faculty of Dentistry, UFG, Goiania, Goias, Brazil CRISTIANA MARINHO JESUS-FRANÇA 100319475328460011804 100319475328460011804 No Department of Paediatric Dentistry, Faculty of Dentistry, Unievangelica Centro Universitário, Anápolis, Goiás, Brasil DENISE ESPÍNDOLA ANTUNES 100319475328460011805 100319475328460011805 No Health Sciences Graduate Program, UFG, Goiania, Goias, Brazil HUGO SÉRGIO OLIVEIRA GOMES 100319475328460011806 100319475328460011806 No Division of Anaesthesiology, Federal University of Goiás (UFG), Goiânia, Goiás, Brazil ONOFRE ALVES NETO 100319475328460011807 100319475328460011807 No Division of Anaesthesiology, Federal University of Goiás (UFG), Goiânia, Goiás, Brazil