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fa Pretreatment 18F-FDG PET standardized uptake value of primary tumor and neck lymph nodes as a predictor of distant metastasis for patients with nasopharyngeal carcinoma جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research Objectives To evaluate the prognostic value of maximum standardized uptake value (SUVmax) measured in [18F]-fluorodeoxyglucose positron emission tomography (18F-FDG PET) for patients with non-disseminated nasopharyngeal carcinoma (NPC). Materials and methods From January 2002 to July 2008, 371 NPC patients who underwent 18F-FDG-PET before radical intensity-modulated radiotherapy (IMRT) were recruited. The SUVmax was recorded for the primary tumor (SUVmax-T) and neck lymph nodes (SUVmax-N). Results The median follow-up was 64months. The optimal cutoff value was 9.3 for SUVmax-T and 7.4 for SUVmax-N. Patients with a lower SUVmax-T or SUVmax-N had a significantly better 5-year distant metastasis-free survival (DMFS), but showed no significant difference in local control or regional control. Patients were divided into four groups by SUVmax, as follows: (a) both lower SUVmax-T and SUVmax-N, (b) higher SUVmax-T only, (c) higher SUVmax-N only, and d) both higher SUVmax-T and SUVmax-N. There were significant differences between these four groups in 5-year DMFS: (a) 95.5%, (b) 90.0%, (c) 83.3%, and (d) 79.9%, respectively (p=0.004). When looking at the stage of disease, the 5-year DMFSs in group a, b, c, d were 96.9%, 94.6%, 97.4%, and 84.3%, respectively in stage I–III patients (p=0.037) and were 91.6%, 82.9%, 68.5%, and 76.7% in stage IVA–B patients (p=0.145). Using multivariate analysis, the SUVmax grouping, gender, and stage were independent factors for DMFS. Conclusion The SUVmax of the primary tumor and neck lymph nodes were independent prognostic factors for DMFS in NPC patients treated with IMRT. <hr> Source: Journal of Oral Oncology <a href="http://www.oraloncology.com/article/S1368-8375(12)00274-6/abstract" target="_blank">Full Text</a> Nasopharyngeal carcinoma, Intensity-modulated radiotherapy, Prognosis, 18F-fluorodeoxyglucose positron emission tomography, Distant metastasis 0 0 http://idai.ir/browse.php?a_code=A-10-32-2442&slc_lang=fa&sid=1 Tsung-Min Hung 100319475328460011591 100319475328460011591 No Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Hung-Ming Wang 100319475328460011592 100319475328460011592 No Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Chung-Jan Kang 100319475328460011593 100319475328460011593 No Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Shiang-Fu Huang 100319475328460011594 100319475328460011594 No Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Chun-Ta Liao 100319475328460011595 100319475328460011595 No Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Sheng-Chieh Chan 100319475328460011596 100319475328460011596 No Department of Nuclear Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Shu-Hang Ng 100319475328460011597 100319475328460011597 No Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan I-How Chen 100319475328460011598 100319475328460011598 No Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Chien-Yu Lin 100319475328460011599 100319475328460011599 No Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Joseph Tung-Chieh Chang 100319475328460011600 100319475328460011600 Yes Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan