fa Diet and risk of oral potentially malignant disorders in rural Sri Lanka بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background</strong></p><p>  While the protective role of antioxidant nutrients against cancer is well established, data on Asian diets in patients with oral cancer are meagre. </p><p> <strong>Methods</strong></p><p>  A total of 1029 subjects over 30 years of age were investigated on their dietary practices in the Sabaragamuwa province (Sri Lanka) in 2006–07. Data collection tools were an interviewer-administered questionnaire, a three-day food diary and an examination of the oral cavity. Subjects identified with Oral Potentially Malignant Disorders (OPMD) and disease-free controls were analysed in a case–control fashion. Among the OPMDs, those with leukoplakia were separately considered. A further subgroup analysis was undertaken for β-carotene-rich foods. The analysis was stratified by portions of fruit/vegetables consumed as five or more portions and two or more portions daily. </p><p> <strong>Results</strong></p><p>  A low BMI (<18.5) was a significant independent risk factor for the development of OPMD. More than half of both cases and controls consumed less than two portions of fruit/vegetables per day and only 20 subjects consumed more than five portions per day. Intake of more than two portions per day of β-carotene-containing fruits/vegetables significantly reduced the risk of having an OPMD and leukoplakia (OR = 0.5 95% CI, 0.3–0.9). The significant differences observed with BMI and fruits/vegetables were attenuated when adjusted for betel quid chewing, smoking and alcohol use. </p><p> <strong>Conclusions</strong> </p><p> This study discloses prevailing under-nutrition in this rural population with very low daily consumption of fruit/vegetables. Cancer preventive properties in their diets are limited and are swamped by the known carcinogenic agents associated with use of betel quid, tobacco and alcohol. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12067/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-2302&slc_lang=fa&sid=1 Hemantha K. Amarasinghe hemanthaamarasinghe@yahoo.com 100319475328460010959 100319475328460010959 Yes National Cancer Control Programme, Colombo 05, Sri Lanka Udaya Usgodaarachchi 100319475328460010960 100319475328460010960 No Family Health Bureau, Colombo 05, Sri Lanka Menaka Kumaraarachchi 100319475328460010961 100319475328460010961 No Oral Health Institute, Maharagama, Sri Lanka Newell W. Johnson 100319475328460010962 100319475328460010962 No Griffith Health Institute, Population and Social Health Research Programme, Gold Coast Campus, Griffith University, Gold Coast, Qld, Australia Saman Warnakulasuriya 100319475328460010963 100319475328460010963 No Oral Medicine, King's College, London, UK/WHO Collaborating Centre for Oral Cancer, London, UK