fa Laboratory methods and biomarkers in the evaluation of bisphosphonate effects on body tissues: a literature review پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research Bisphosphonates are extensively used to treat bone metabolism disorders meanwhile, these drugs have important side effects such as jaw osteonecrosis and femoral fracture. Therefore, studies have been conducted aimed at better understanding their mechanism of action and determining a course of action to avoid these side effects. We present here a literature review focusing on the laboratory methods available for investigating bisphosphonate effects on body tissues. There are many different methods available for this purpose, but the appropriate application of these methods and knowledge of their limitations are crucial for understanding the effects of bisphosphonates. <hr><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12031/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> biomarkers;bisphosphonates;body tissues;laboratory methods 0 0 http://idai.ir/browse.php?a_code=A-10-32-2291&slc_lang=fa&sid=1 Ana Carolina Uchoa Vasconcelos 100319475328460010879 100319475328460010879 No Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil Soraya de Azambuja Berti-Couto 100319475328460010880 100319475328460010880 No Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil Maria Antonia Figueiredo 100319475328460010881 100319475328460010881 No Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil Fernanda Gonçalves Salum 100319475328460010882 100319475328460010882 No Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil Tiago Giuliani Lopes 100319475328460010883 100319475328460010883 No Department of Pathology, School of Medicine, Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil Karen Cherubini karen.cherubini@pucrs.br 100319475328460010884 100319475328460010884 Yes Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Porto Alegre, RS, Brazil