fa Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamous cell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain. In conclusion, galectin-9 is expressed in the majority of samples of normal epithelium, along with regular presence of keratins 14 or 19. This lectin can represent a potential marker of normality in the cases of the studied squamous cell epithelia. <hr><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2012.01185.x/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> agglutinin;basal cells;epithelium;keratin;lectin;tumor 0 0 http://idai.ir/browse.php?a_code=A-10-32-2232&slc_lang=fa&sid=1 Zdeněk Fík 100319475328460010524 100319475328460010524 No Institute of Anatomy, 1st Faculty of Medicine, Charles University, U Nemocnice, Prague, Czech Republic/Department of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Jaroslav Valach 100319475328460010525 100319475328460010525 No Department of Stomatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Martin Chovanec 100319475328460010526 100319475328460010526 No Institute of Anatomy, 1st Faculty of Medicine, Charles University, U Nemocnice, Prague, Czech Republic/Department of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Jiří Mazánek 100319475328460010527 100319475328460010527 No Department of Stomatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Roman Kodet 100319475328460010528 100319475328460010528 No Institute of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic Ondřej Kodet 100319475328460010529 100319475328460010529 No Institute of Anatomy, 1st Faculty of Medicine, Charles University, U Nemocnice, Prague, Czech Republic/Department of Dermatovenereology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Ruth Tachezy 100319475328460010530 100319475328460010530 No Department of Experimental Virology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic Eva Foltynová 100319475328460010531 100319475328460010531 No Department of Stomatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Sabine André 100319475328460010532 100319475328460010532 No Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Ludwig-Maximilians University, Munich, Germany Karel Smetana Jr karel.smetana@lf1.cuni.cz 100319475328460010533 100319475328460010533 Yes Institute of Anatomy, 1st Faculty of Medicine, Charles University, U Nemocnice, Prague, Czech Republic