fa OPG and RANKL levels around miniscrew implants during orthodontic tooth movement ارتودنسی Orthodontics پژوهشي Research <p> <strong>Introduction</strong></p><p>  The aim of this study was to determine the peri-miniscrew implant crevicular fluid receptor activator of nuclear factor-кB ligand (RANKL) and osteoprotegerin (OPG) levels around loaded and unloaded miniscrew implants at different time intervals. </p><p> <strong>Methods</strong></p><p>  Twenty loaded and 16 unloaded miniscrew implants were included in this study. All miniscrew implants were placed bilaterally between the maxillary second premolars and first molars as anchorage units for canine distalization. Peri-miniscrew implant crevicular fluid was taken from the mesiobuccal aspects of the loaded and unloaded miniscrew implants before loading at 24, 48, and 168 hours and on day 30 after force application. Enzyme-linked immunosorbent assay kits were used to determine RANKL and OPG levels in the peri-miniscrew implant crevicular fluid samples. Wilcoxon, Mann-Whitney U, and Spearman correlation tests were used for statistical evaluations at the P <0.05 level. </p><p> <strong>Results</strong></p><p>  Although the total amount of OPG was not different between the groups, the total amount of RANKL was significantly elevated in the loaded miniscrew implant group (P <0.05) at all time periods. Peri-miniscrew implant crevicular fluid volume was the highest at 48 hours in the loaded group. Also, the OPG/RANKL ratio in the peri-miniscrew implant crevicular fluid was significantly decreased in the loaded miniscrew implant group. </p><p> <strong>Conclusions</strong></p><p>  The OPG and RANKL levels vary around loaded and unloaded miniscrew implants as a result of force application. </p><hr><p></p><p> <strong>Source: </strong>American Journal of Orthodontics & Dentofacial Orthopedics </p><p> <a href="http://www.ajodo.org/article/S0889-5406(13)00390-9/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1832&slc_lang=fa&sid=1 Sukru Enhos 10031947532846008622 10031947532846008622 No Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey Ilknur Veli 10031947532846008623 10031947532846008623 No Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey Omer Cakmak 10031947532846008624 10031947532846008624 No Department of Periodontology, Faculty of Dentistry, Erciyes University, Kayseri, Turkey Faruk Izzet Ucar 10031947532846008625 10031947532846008625 No Department of Orthodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey Arzu Alkan 10031947532846008626 10031947532846008626 No Department of Periodontology, Faculty of Dentistry, Erciyes University, Kayseri, Turkey Tancan Uysal 10031947532846008627 10031947532846008627 Yes Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey