fa WWOX expression in giant cell lesions of the jaws پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  To investigate WWOX messenger RNA (mRNA) transcriptional levels in giant cell lesions (GCLs) of the jaws and associate its expression with clinical parameters. </p><p> <strong>Study design</strong></p><p>  In this pilot study, quantitative reverse-transcription polymerase chain reaction was performed to analyze WWOX expression in 6 central giant cell lesions (CGCLs) (including 2 aggressive), 5 peripheral giant cell lesions (PGCLs) and 1 cherubism sample. Immunohistochemistry was performed to confirm the localization of the Wwox protein. </p><p> <strong>Results</strong></p><p>  CGCL and PGCL showed an overall increased expression of WWOX, as did the cherubism case, but no differences were observed among the groups. Wwox was localized almost entirely to the cytoplasm of multinucleated giant cells, as well as in a few mononuclear cells. CGCL and PGCL showed higher expression of the WWOX mRNA than peripheral blood mononuclear cells. The 2 aggressive CGCL samples exhibited decreased WWOX expression.</p><p> <strong> Conclusions</strong></p><p>  These results showed increased expression of WWOX mainly in non-aggressive GCLs of the jaws. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p><a href="http://www.oooojournal.net/article/S2212-4403(13)00235-6/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1683&slc_lang=fa&sid=1 Fabrício Rezende Amaral 10031947532846007915 10031947532846007915 No Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Marina Gonçalves Diniz 10031947532846007916 10031947532846007916 No Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Vanessa Fátima Bernardes 10031947532846007917 10031947532846007917 No Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Paulo Eduardo Alencar Souza 10031947532846007918 10031947532846007918 No Department of Dentistry, Catholic University of Minas Gerais, Belo Horizonte, Brazil Ricardo Santiago Gomez 10031947532846007919 10031947532846007919 No Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Carolina Cavaliéri Gomes 10031947532846007920 10031947532846007920 Yes Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil