fa Articaine (4%) with epinephrine (1:100,000 or 1:200,000) in intraosseous injections in symptomatic irreversible pulpitis of mandibular molars: anesthetic efficacy and cardiovascular effects جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Objective</strong></p><p>  The aim of this study was to compare the cardiovascular effects and the anesthetic efficacy of intraosseous injections of 4% articaine with 1:100,000 epinephrine (EPI100) or 4% articaine with 1:200,000 epinephrine (EPI200). </p><p> <strong>Study Design</strong></p><p>  In this prospective, randomized, double-blind study, 0.9 mL EPI100 and EPI200 solutions were administered for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis in 60 patients. The anesthetic success and pain during anesthesia were evaluated by visual analog scale. The cardiovascular parameters evaluated were heart rate, diastolic/systolic blood pressure, pulse oximetry, and electrocardiogram changes. </p><p> <strong>Results</strong></p><p>  Both solutions provided high anesthetic efficacy (96.8% and 93.1% for EPI100 and EPI200, respectively P > .05), and the cardiovascular parameters showed minimal incidences of significant differences throughout the clinical procedure. </p><p> <strong>Conclusions</strong></p><p>  The epinephrine concentration did not affect the efficacy of 4% articaine, and both solutions produced a high success level of pulpal anesthesia. Intraosseous delivery by slow speed of injection did not induce significant clinical changes in cardiovascular parameters. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)00182-4/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1674&slc_lang=fa&sid=1 Leandro Augusto Pinto Pereira 10031947532846007861 10031947532846007861 Yes Department of Pharmacology, Anesthesiology, and Therapeutics, São Leopoldo Mandic Dental School, Campinas, Brazil Francisco Carlos Groppo 10031947532846007862 10031947532846007862 No Department of Pharmacology, Anesthesiology, and Therapeutics, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil Christiane de Cássia Bergamaschi 10031947532846007863 10031947532846007863 No Department of Pharmaceutical Scienses, School of Pharmacy of Sorocaba, University of Sorocaba, Sorocaba, Brazil John Gerard Meechan 10031947532846007864 10031947532846007864 No Dental School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom Juliana Cama Ramacciato 10031947532846007865 10031947532846007865 No Department of Pharmacology, Anesthesiology, and Therapeutics, São Leopoldo Mandic Dental School, Campinas, Brazil Rogério Heládio Lopes Motta 10031947532846007866 10031947532846007866 No Department of Pharmacology, Anesthesiology, and Therapeutics, São Leopoldo Mandic Dental School, Campinas, Brazil José Ranali 10031947532846007867 10031947532846007867 No Department of Pharmacology, Anesthesiology, and Therapeutics, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil