fa Carcinoma ex-pleomorphic adenoma of upper lip showing copy number loss of tumor suppressor genes پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Background </strong></p><p> Carcinoma ex-pleomorphic adenoma (CXPA) is a malignant salivary gland tumor that arises rarely in the minor salivary glands. Although the etiology of CXPA remains unclear, the role of some tumor suppressor genes and oncogenes in CXPA is documented however, other genes still need to be studied. </p><p> <strong>Study design</strong></p><p>  and objective An uncommon case of CXPA involving the upper lip is presented, which was analyzed by a panel of tumor suppressor genes by multiplex ligation-dependent probe amplification. </p><p> <strong>Results</strong></p><p>  The genes investigated in this study, a loss of copy number was detected for CASP8, CD44, CDH1, DAPK1, ESR1, RASSF1, and TP73. Immunohistochemical reactions for the validation of some of these results showed negativity for CD44, RASSF1, and p73. </p><p> <strong>Conclusion</strong> </p><p> A loss of copy number of the genes CD44, RASSF1, and TP73 may contribute to the carcinogenesis of CXPAs. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00003-5/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1661&slc_lang=fa&sid=1 Fernanda Viviane MAriano 10031947532846007797 10031947532846007797 No Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brasil Daniel Rincon 10031947532846007798 10031947532846007798 Yes Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil Rogério Oliveira Gondak 10031947532846007799 10031947532846007799 No Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brasil Rogério Jorge 10031947532846007800 10031947532846007800 No Oral Diagnosis Service, Association of Dental Surgeons of Campinas (ACDC), Campinas, Brazil Márcio Ajudarte Lopes 10031947532846007801 10031947532846007801 No Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brasil Albina Altemani 10031947532846007802 10031947532846007802 No Department of Pathology Anatomy, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil Oslei PAed de Almeida 10031947532846007803 10031947532846007803 No Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brasil Luiz Paulo Kowalski 10031947532846007804 10031947532846007804 No Department of Head and Neck and Otorhinolaryngology, AC Camargo Hospital, São Paulo, Brazil