fa Gardner's syndrome: a clinical and genetic study of a family جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Objective</strong></p><p>  Gardner syndrome (GS) is an autosomal dominant genetic disorder with almost complete penetrance (80%) and variable expression. GS is a variant of familial adenomatous polyposis and characterized by extracolonic manifestations including osteomas and soft tissue tumors (desmoid tumors, epidermoid cysts). We describe clinical and surgical approaches in a family in which the genetic disorder was diagnosed in 3 generations. </p><p> <strong>Study Design</strong></p><p>  The studied family underwent clinical history and instrumental and genomic studies. Two members of this family, affected with GS, underwent surgery for skeletal osteomas. </p><p> <strong>Results</strong></p><p>  The patients that we treated with clinical-instrumental monitoring for a period of 5 years had no major disturbances of the stomatognathic system and no clinical signs of pathology of the gastrointestinal tract, eyes, or endocrine systems. </p><p> <strong>Conclusions</strong> </p><p> The orofacial complex disorders are exclusively functional and esthetic, concerning primarily the stomatognathic system. We had no cases of malignant transformation of osteomatosis lesions. Clinical sequelae are manly facial eumorphy and occlusion problems of the temporomandibular joint. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)00125-3/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1547&slc_lang=fa&sid=1 Maria Giulia Critofaro 10031947532846007131 10031947532846007131 Yes Department of Oral and Maxillofacial Surgery, University Magna Graecia of Catanzaro, Viale Europa, 211, Germaneto di Catanzaro, 88100 Catanzaro, Italy Amerigo Giudice 10031947532846007132 10031947532846007132 No Department of Oral and Maxillofacial Surgery, University Magna Graecia of Catanzaro, Viale Europa, 211, Germaneto di Catanzaro, 88100 Catanzaro, Italy Massimiliano Amantea 10031947532846007133 10031947532846007133 No Umberto Riccelli 10031947532846007134 10031947532846007134 No Mario Giudice 10031947532846007135 10031947532846007135 No