fa Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Background</strong></p><p>  PERP is a p53/p63-regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression. </p><p> <strong>Study Design</strong></p><p>  We evaluated PERP expression in different grades of oral dysplasia (34 cases) and at different stages of invasive squamous cell carcinoma (SCC), and correlated the latter with clinical outcome. A tissue microarray consisting of nondysplastic mucosa, carcinoma in situ, SCC, and nodal metastases from 33 patients with human papilloma virus–negative SCC was stained for PERP and E-cadherin. </p><p> <strong>Results</strong> </p><p> Complete loss of PERP expression was associated with worse local control in patients with SCC. The 5-year local control rate was 91% for patients with partial PERP loss versus 31% for those with complete loss (P = .01). </p><p> <strong>Conclusions</strong> </p><p> This is the first study to show that loss of PERP expression correlates with the transition to SCC and with increased local relapse in patients with oral cavity SCC. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p><a href="http://www.oooojournal.net/article/S2212-4403(12)01677-X/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1505&slc_lang=fa&sid=1 Christina S. Kong 10031947532846006872 10031947532846006872 Yes Department of Pathology, Stanford University, Stanford, California Hongbin Cao 10031947532846006873 10031947532846006873 No Department of Radiation Oncology, Stanford University, Stanford, California Shiley Kwok 10031947532846006874 10031947532846006874 No Department of Pathology, Stanford University, Stanford, California Catherine M.Nguyen 10031947532846006875 10031947532846006875 No Department of Pathology, Stanford University, Stanford, California Richard S.Jordan 10031947532846006876 10031947532846006876 No Department of Orofacial Sciences, Pathology, and Radiation Oncology, University of California, San Francisco, California Veronica G. Beaurdy 10031947532846006877 10031947532846006877 No Department of Radiation Oncology, Stanford University, Stanford, California Laura D. Attardi 10031947532846006878 10031947532846006878 No Department of Radiation Oncology, Stanford University, Stanford, California Quynh-Thu Le 10031947532846006879 10031947532846006879 No Department of Radiation Oncology, Stanford University, Stanford, California