fa The binary oral dysplasia grading system: validity testing and suggested improvement پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objectives</strong> A binary system is reputed to be superior to the World Health Organization (WHO) system in grading oral dysplasia. We aimed to validate its reproducibility and prognostic ability and examine whether it could be improved. </p><p> <strong>Study Design</strong></p><p>  Three pathologists graded 141 oral epithelial dysplasia biopsies with the use of both systems. Observer variability and prognostic ability were assessed with the use of kappa and logistic regression models. </p><p> <strong>Results</strong></p><p> <strong> </strong>The binary system showed superior agreement to the WHO system (multirater kappa 0.59 vs. 0.49, respectively) but similar prognostic ability (odds ratio [OR] 4.59 [P = .014] vs. OR 2.25 [P = .02], respectively). Adding smoking and alcohol slightly improved the prognostic ability of both systems (OR 5.10 vs. OR 2.42, respectively). Our new binary system with a refined diagnostic threshold demonstrated a slightly greater prognostic ability and improved ability to differentiate between high- and low-risk moderate dysplasia cases. </p><p> <strong>Conclusions</strong></p><p> <strong> </strong>The binary system has similar prognostic ability but superior reproducibility compared with the WHO system. Prognostication is improved still further by using a new threshold. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01651-3/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1504&slc_lang=fa&sid=1 Paul Nankivel 10031947532846006865 10031947532846006865 No Institute of Head and Neck Studies and Education (InHANSE), University of Birmingham, Birmingham, UK Hazel Williams 10031947532846006866 10031947532846006866 No Queen Elizabeth Hospital, Birmingham, UK Paul Mattews 10031947532846006867 10031947532846006867 No University Hospital Coventry and Warwickshire, Coventry, UK Sari Suortamo 10031947532846006868 10031947532846006868 No University Hospital Coventry and Warwickshire, Coventry, UK David Snead 10031947532846006869 10031947532846006869 No University Hospital Coventry and Warwickshire, Coventry, UK Cristopher Mcconkey 10031947532846006870 10031947532846006870 No Clinical Trials Unit, Warwick Medical School, Coventry, UK Hisham Mehanna 10031947532846006871 10031947532846006871 Yes Institute of Head and Neck Studies and Education (InHANSE), University of Birmingham, Birmingham, UK