fa Electrically conductive bacterial nanowires in bisphosphonate-related osteonecrosis of the jaw biofilms پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  Bacterial biofilms play a role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The purpose of this preliminary study was to test the hypothesis that the extracellular filaments observed in biofilms associated with BRONJ contain electrically conductive nanowires. </p><p> <strong>Study Design</strong></p><p>  Bone samples of patients affected by BRONJ were evaluated for conductive nanowires by scanning electron microscopy (SEM) and conductive probe atomic force microscopy (CP-AFM). We created nanofabricated electrodes to measure electrical transport along putative nanowires. </p><p> <strong>Results </strong></p><p> SEM revealed large-scale multispecies biofilms containing numerous filamentous structures throughout necrotic bone. CP-AFM analysis revealed that these structures were electrically conductive nanowires with resistivities on the order of 20 Ω·cm. Nanofabricated electrodes spaced along the nanowires confirmed their ability to transfer electrons over micron-scale lengths. </p><p> <strong>Conclusions</strong> </p><p> Electrically conductive bacterial nanowires to date have been described only in environmental isolates. This study shows for the first time that these nanowires can also be found in clinically relevant biofilm-mediated diseases, such as BRONJ, and may represent an important target for therapy. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p><a href="http://www.oooojournal.net/article/S2212-4403(12)01499-X/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1502&slc_lang=fa&sid=1 Greg Wanger 10031947532846006852 10031947532846006852 No Electromicrobiology Group, J. Craig Venter Institute, San Diego, California Yuri Gorby 10031947532846006853 10031947532846006853 No Department of Biological Sciences, University of Southern California, Los Angeles, California Mohamad Y. El-Nagaar 10031947532846006854 10031947532846006854 No Department of Physics, University of Southern California, Los Angeles, California Thomas D. Yuzvinsky 10031947532846006855 10031947532846006855 No Department of Physics, University of Southern California, Los Angeles, California Cristoph Schaudin 10031947532846006856 10031947532846006856 No Center for Biological Security, Robert Koch Institute, Berlin, Germany Amita Gorur 10031947532846006857 10031947532846006857 No Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California Parish P.Sedgizadeh 10031947532846006858 10031947532846006858 Yes Center for Biofilms, University of Southern California, Los Angeles, California