en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> The purpose of the present study is to evaluate the 10-year results following treatment of intrabony defects treated with an enamel matrix protein derivative (EMD) combined with either a natural bone mineral (NBM) or β-tricalcium phosphate (β-TCP). </p><p> <strong>Methods</strong>: Twenty-two patients with advanced chronic periodontitis and displaying one deep intrabony defect were randomly treated with a combination of either EMD + NBM or EMD + β-TCP. Clinical evaluations were performed at baseline and at 1 and 10 years. The following parameters were evaluated: plaque index, bleeding on probing, probing depth, gingival recession, and clinical attachment level (CAL). The primary outcome variable was CAL. </p><p> <strong>Results:</strong> The defects treated with EMD + NBM demonstrated a mean CAL change from 8.9 ± 1.5 mm to 5.3 ± 0.9 mm (P <0.001) and to 5.8 ± 1.1 mm (P <0.001) at 1 and 10 years, respectively. The sites treated with EMD + β-TCP showed a mean CAL change from 9.1 ± 1.6 mm to 5.4 ± 1.1 mm (P <0.001) at 1 year and 6.1 ± 1.4 mm (P <0.001) at 10 years. At 10 years two defects in the EMD + NBM group had lost 2 mm, whereas two other defects had lost 1 mm of the CAL gained at 1 year. In the EMD + β-TCP group three defects had lost 2 mm, whereas two other defects had lost 1 mm of the CAL gained at 1 year. Compared with baseline, at 10 years, a CAL gain of ≥3 mm was measured in 64% (i.e., seven of 11) of the defects in the EMD + NBM group and in 82% (i.e., nine of 11) of the defects in the EMD + β-TCP group. No statistically significant differences were found between the 1- and 10-year values in either of the two groups. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and 10 years. </p><p> <strong>Conclusion</strong>: Within their limitations, the present findings indicate that the clinical improvements obtained with regenerative surgery using EMD + NBM or EMD + β-TCP can be maintained over a period of 10 years. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p><a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120238" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Bone grafting, enamel matrix proteins, periodontitis, randomized controlled trial, regenerative medicine 0 0 http://idai.ir/browse.php?a_code=A-10-32-1307&slc_lang=en&sid=1 Ferenc Döri 10031947532846005803 10031947532846005803 No Department of Periodontology, Semmelweis University, Budapest, Hungary Nicole B. Arweiler 10031947532846005804 10031947532846005804 No Department of Periodontology, University of Marburg, Marburg, Germany Erika Szántó 10031947532846005805 10031947532846005805 No Department of Periodontology, Semmelweis University, Budapest, Hungary Anikó Ágics 10031947532846005806 10031947532846005806 No Department of Periodontology, Semmelweis University, Budapest, Hungary István Gera 10031947532846005807 10031947532846005807 No Department of Periodontology, Semmelweis University, Budapest, Hungary Anton Sculean anton.sculean@zmk.unibe.ch 10031947532846005808 10031947532846005808 Yes Department of Periodontology, Dental School, University of Bern, Bern, Switzerland