en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very important and powerful antioxidants that have been used for the treatment of many diseases. The present study aims to investigate the role of ALA and Vit-C substances in the treatment of alveolar bone resorption in periodontal diseases. </p><p> <strong>Methods:</strong> Thirty-six male Wistar albino rats were randomly divided into four groups as follows: 1) control rats 2) rats with experimental periodontitis (PED) 3) rats with PED treated with ALA (ALA) and 4) rats with PED treated with ALA+Vit-C (ALA+Vit-C). PED was simulated by placing ligatures around the neck of teeth for 5 weeks. After ligature removal, the PED group was given a single intragastric dose of 1 mL saline, and the ALA and ALA+Vit-C groups were treated with an intragastric dose of 50 mg/kg ALA and ALA+Vit-C for 15 days, respectively. Levels of serum bone alkaline phosphatase (B-ALP) and myeloperoxidase (MPO) activity in gingival tissues were analyzed. To evaluate the osteoclast activation, expression of activated receptor activator nuclear factor-kappa B ligand (RANKL) and bone density index (BDI) were determined stereologically in the bone sections obtained from the mandibles of the rats. </p><p> <strong>Results</strong>: The results showed statistically significant differences between the PED group and groups treated with antioxidant according to B-ALP, MPO, RANKL, and BDI values (P <0.05). ALA and ALA+Vit-C treatments showed beneficial effects on the mesial/distal periodontal bone support at the ligature-induced periodontitis tooth areas. </p><p> <strong>Conclusion:</strong> This study shows that ALA and Vit-C treatment provides therapeutic effects on inhibition of alveolar bone resorption and periodontal tissue destruction. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120252" target="_blank"><font color="#0000ff">Full Text</font></a></p> Antioxidants, oxidative stress, periodontitis, periodontium, pharmaceutical preparations 0 0 http://idai.ir/browse.php?a_code=A-10-32-1298&slc_lang=en&sid=1 Sumeyra Akman akslepios3191@hotmail.com 10031947532846005747 10031947532846005747 Yes Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey Varol Canakci 10031947532846005748 10031947532846005748 No Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey Adem Kara 10031947532846005749 10031947532846005749 No Department of Histology and Embryology, Faculty of Veterinary Medicine, Atatürk University Ummuhan Tozoglu 10031947532846005750 10031947532846005750 No Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Akdeniz University, Antalya, Turkey Taner Arabaci 10031947532846005751 10031947532846005751 No Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey İlhan Metin Dagsuyu 10031947532846005752 10031947532846005752 No Department of Orthodontics, Faculty of Dentistry, Eskişehir Osmangazi University, Eskişehir, Turkey