en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> The aim of this study is to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive therapy to scaling and root planing (SRP) for the treatment of experimentally induced periodontitis in rats with ovariectomy (OVX) that are or are not treated with estrogen replacement. </p><p> <strong>Methods:</strong> A total of 270 female rats were divided into three groups: 1) normal rats 2) rats with OVX and 3) rats with OVX with estrogen replacement. Periodontal disease was induced through the introduction of a cotton thread around the mandibular left first molar. After 7 days, the ligature was removed, and the rats were randomly divided into the following treatment groups: 1) SRP plus saline solution 2) SRP plus low-level laser therapy (LLLT) and 3) SRP plus toluidine blue O irrigation followed by LLLT. Ten rats from each group were euthanized at days 7, 15, and 30 after dental treatment. Bone loss (BL) in the furcation region was evaluated using histometric and immunohistochemical analyses. </p><p> <strong>Results:</strong> aPDT treatment resulted in reduced BL compared with SRP treatment at all time points. Additionally, rats treated with aPDT exhibited reduced numbers of tartrate-resistant acid-phosphatase–positive cells and more proliferating cell nuclear antigen–positive cells in all treatment groups regardless of estrogen status. Whereas rats treated with aPDT showed weak immunoreactivity to the receptor activator of nuclear factor-κ B ligand at day 7 post-treatment, strong osteoprotegerin immunoreactivity was observed at day 15 post-treatment. <strong></strong></p><p> <strong>Conclusion:</strong> aPDT is an effective adjunctive therapy for the treatment of periodontitis in rats with OVX that are or are not given estrogen replacement therapy. </p><hr><p></p><p> <strong>Source: </strong>Journal of Periodentology </p><p> <a href="http://www.joponline.org/doi/abs/10.1902/jop.2012.120163" target="_blank"><font color="#0000ff">Full Text</font></a></p> Alveolar bone loss, estrogen replacement therapy, lasers, ovariectomy, periodontitis, photochemotherapy 0 0 http://idai.ir/browse.php?a_code=A-10-32-1287&slc_lang=en&sid=1 Valdir Gouveia Garcia vgouveia@foa.unesp.br 10031947532846005679 10031947532846005679 Yes Group for the Research and Study of Laser in Dentistry, Department of Surgery and Integrated Clinic, Division of Periodontics, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil/Master Course, University Center of the Educational Foundation of Barretos, Dental School of Barretos, Barretos, São Paulo, Brazil Erivan Clementino Gualberto Júnior 10031947532846005680 10031947532846005680 No Group for the Research and Study of Laser in Dentistry, Department of Surgery and Integrated Clinic, Division of Periodontics, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil Leandro Araújo Fernandes 10031947532846005681 10031947532846005681 No Department of Clinic and Surgery, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil Alvaro Francisco Bosco 10031947532846005682 10031947532846005682 No Group for the Research and Study of Laser in Dentistry, Department of Surgery and Integrated Clinic, Division of Periodontics, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil Maria José Hitomi Nagata 10031947532846005683 10031947532846005683 No Group for the Research and Study of Laser in Dentistry, Department of Surgery and Integrated Clinic, Division of Periodontics, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil Cláudio Aparecido Casatti 10031947532846005684 10031947532846005684 No Department of Basic Science, UNESP Edilson Ervolino 10031947532846005685 10031947532846005685 No Department of Basic Science, UNESP Letícia Helena Theodoro 10031947532846005686 10031947532846005686 No Group for the Research and Study of Laser in Dentistry, Department of Surgery and Integrated Clinic, Division of Periodontics, University Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil