Mojgan Alaeddini1, Shahroo Etemad- Moghadam,Fereshteh Baghaee
Dental Research Centre,Faculty of Dentistry, Medical Sciences/ University of Tehran,Tehran,Iran.
Calretinin, a calcium-binding protein,is expresses primarily in certain subtypes of neurons. It has also been reported to be present in mesotheliomas and other tumours.The aim was to determine the expression of calretinin in selected odontogenic neoplasms.
Immunohistochemistry for calretinin was performed on 55 odontogenic tumors consisting od 20 solid ameloblastomas,five calcifying epithelial odontogenic tumors, 10 adenomatoid odontogenic tumors,10 ameloblastic fibromas and 10 odontogenic myxomas. The distribution,intensity,pattern and localization of immunoreactive cells were determined by conventional light microscopy. X2 test was used for statistical analysis and P < 0.05 was considered to be significant. All 20 ameloblastomas showed intense immunopositivity with a diffuse distribution pattern. None of calretinin expression between groups were statistically significant at P < 0.001.
Considering that ameloblastomas,in contrast to the other studied tumours,were consistently reactive for calretinin,this protein may have a role in the pathogenesis of this aggresive neoplasm.