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:: Volume 6, Issue 6 (1-2012) ::
3 2012, 6(6): 0-0 Back to browse issues page
Individual Composition of Human Leukocyte Antigens and Periodontopathogens in the Background of Periodontitis
Stefan Reichert * , Wolfgang Altermann , Jamal M. Stein , Hans-Günter Schaller , Helmut K.G. Machulla , Susanne Schulz
Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany
Abstract:   (1464 Views)

 Background: Human leukocyte antigens (HLAs) are a basic precondition to induce the immune response to pathogens. Therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and HLAs to test their impact together with additional risk factors in multivariate analyses.

 Methods: Eighty-five patients with generalized aggressive periodontitis (GAgP) and 71 patients with generalized chronic periodontitis (CP) were compared to 88 periodontitis-free controls. HLA Class I and II typing was performed by polymerase chain reaction (PCR) with sequence-specific primers. Subgingival plaque specimens were detected by PCR with sequence-specific oligonucleotides. Risk-factor analyses were performed with respect to the cofactors age, sex, smoking, and plaque level by logistic regression.

 Results: In the total patient group (GAgP + CP), the adjusted odds ratio (OR) of periodontitis was decreased in cases who were carriers of HLA-B*57 (OR = 0.259, 95% confidence interval [CI] = 0.086 to 0.782), HLA-DQB1*08 (OR = 0.404, 95% CI = 0.187 to 0.871), or the combination HLA-DRB1*04DRB4*DQB1*0302 (OR = 0.407, 95% CI = 0.185 to 0.895). Moreover, individuals who expressed HLA-DRB1*04 (OR = 0.36, 95% CI = 0.148 to 0.886) or HLA-DRB1*04DRB4*DQB1*0302 (OR = 0.29, 95% CI = 0.092 to 0.884) had a decreased colonization risk with Aggregatibacter actinomycetemcomitans.

 Conclusions: Certain HLA markers were negatively associated to the manifestation of a generalized periodontitis and/or the individual colonization of A. actinomycetemcomitans. The underlying mechanisms have to be investigated in future studies.


 Source: Journal of Periodentology

 Full Text

Keywords: Aggressive periodontitis, bacteria, chronic periodontitis, HLA antigens
     
Type of Study: Research | Subject: Periodontology
Received: 2013/07/9 | Published: 2012/01/15
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Reichert S, Altermann W, M. Stein J, Schaller H, K.G. Machulla H, Schulz S. Individual Composition of Human Leukocyte Antigens and Periodontopathogens in the Background of Periodontitis. 3 2012; 6 (6)
URL: http://idai.ir/article-1-1261-en.html


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Volume 6, Issue 6 (1-2012) Back to browse issues page
جامعه اسلامی دندانپزشکان Islamic Dental Association of IRAN

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