en جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Objectives </strong>Elective neck dissection is frequently performed during surgery in head and neck cancer patients. The sentinel lymph node (SLN) procedure can prevent the morbidity of a neck dissection and improve lymph node staging by fine pathology. Near-infrared (NIR) fluorescence imaging is a promising technique to identify the sentinel lymph node (SLN) intraoperatively. This feasibility study explored the use of indocyanine green adsorbed to human serum albumin (ICG:HSA) for SLN mapping in head and neck cancer patients. </p><p> <strong>Materials and methods</strong> A total of 10 consecutive patients with oral cavity or oropharyngeal cancer and a clinical N0 neck were included. After exposure of the neck, 1.6mL of ICG:HSA (500μM) was injected at four quadrants around the tumor. During the neck dissection, levels I–IV were measured for fluorescence using the Mini-FLARE imaging system. </p><p> <strong>Results</strong> In all 10 patients, NIR fluorescence imaging enabled visualization of one or more SLNs. A total of 17 SLNs were identified. The mean contrast between the fluorescent signal of the lymph nodes and of the surrounding tissue was 8.7±6.4. In 3 patients, of which 1 was false-negative, lymph node metastases were found. After administration of ICG:HSA, the average number of fluorescent lymph nodes significantly increased over time (P<0.001). </p><p> <strong>Conclusion</strong> This study demonstrated feasibility to detect draining lymph nodes in head and neck cancer patients using NIR fluorescence imaging. However, the fluorescent tracer quickly migrated beyond the SLN to higher tier nodes. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Oncology </p><p><a href="http://www.oraloncology.com/article/S1368-8375(12)00245-X/abstract" target="_blank"><font color="#0033ff"> Full Text</font></a></p> Near-infrared fluorescence, Image-guided surgery, Oral cavity cancer, Oropharynx cancer, Sentinel lymph node, Indocyanine green 0 0 http://idai.ir/browse.php?a_code=A-10-32-849&slc_lang=en&sid=1 Joost R van der Vorst 10031947532846003674 10031947532846003674 No Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands Boudewijn E. Schaafsma 10031947532846003675 10031947532846003675 No Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands Floris P.R. Verbeek 10031947532846003676 10031947532846003676 No Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands Stijn Keereweer 10031947532846003677 10031947532846003677 No Department of Otorhinolaryngology Head and Neck Surgery, Erasmus Medical Center, Rotterdam, The Netherlands Jeroen C. Jansen 10031947532846003678 10031947532846003678 No Department of Otolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands Lilly-Ann van der Velden 10031947532846003679 10031947532846003679 No Department of Otolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands Antonius P.M. Langeveld 10031947532846003680 10031947532846003680 No Department of Otolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands Cornelis • J.H. van de Velde 10031947532846003681 10031947532846003681 No Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands John • V. Frangioni 10031947532846003682 10031947532846003682 No Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States Alexander L. Vahrmeijer 10031947532846003683 10031947532846003683 Yes Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands