en ارتودنسی Orthodontics پژوهشي Research <p> <strong>Objective:</strong> To determine if the mandibular condylar cartilage (MCC) will grow with and without mandibular anterior repositioning appliances with the administration of insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β). </p><p> <strong>Materials and Methods:</strong> Twenty-four growing New Zealand rabbits were divided into three groups: a group with saline injection in the temporomandibular joint, a group that received anterior positioning appliance, and a group that received injection of growth factors as well as mandibular repositioning appliance. Real-time reverse transcription polymerase chain reaction technique was used to study gene expression supported by histomorphometry. </p><p> <strong>Results:</strong> Administration of growth factors along with mandibular repositioning appliances has induced 5.70-fold expression of matrix metalloproteinase-1 (MMP-1) (P < .0005) and 1.29-fold expression of MMP-13 (P < .0005). In contrast, administration of mandibular repositioning appliances only has induced 2.33-fold expression of MMP-1 (P < .0005) and 0.83-fold expression of MMP-13 (P < .0005). Histomorphometric analysis revealed increased proliferation of the condylar cartilage in the appliance and injection group as compared to the control group. </p><p> <strong>Conclusion:</strong> The administration of growth factors along with the use of mandibular advancement appliance has increased genetic expression of MMP-1 and MMP-13 supported by histomorphometric evidence indicating growth of condylar cartilage. </p><hr><p></p><p> <strong>Source: </strong>Angle Orthodontists </p><p><a href="http://www.angle.org/doi/abs/10.2319/122011-780.1" target="_blank"><font color="#0033ff"> Full Text</font></a></p> Transforming growth factor-β (TGF-β), Insulin-like growth factor (IGF-1), Mandibular repositioning appliances, MMP-1, MMP-13, Mandibular condylar cartilage 0 0 http://idai.ir/browse.php?a_code=A-10-32-789&slc_lang=en&sid=1 Amol Patil amolp66@yahoo.com 10031947532846003416 10031947532846003416 Yes Department of Orthodontics and Dentofacial Orthopedics, Bharati Dental College and Hospital, Pune, Maharashtra, India Ravindranath Sable 10031947532846003417 10031947532846003417 No Department of Orthodontics and Dentofacial Orthopedics, Bharati Dental College and Hospital, Pune, Maharashtra, India Ramanlal Kothari 10031947532846003418 10031947532846003418 No Rajiv Gandhi Institute of Biotechnology, Pune, Maharashtra, India