en رادیولوژی دهان، فک و صورت Oral and Maxillofacial Radiology پژوهشي Research <p> <strong>Objectives</strong> The purpose of this prospective study was to characterize the MR relaxometric features of the major salivary glands in patients with sickle cell disease (SCD). </p><p> <strong>Methods </strong>15 patients with SCD (aged 19.8–43.6 years) and 12 controls were imaged with the mixed turbo-spin echo pulse sequence. The major salivary glands were manually segmented and T1, T2 and secular T2 relaxometry histograms were modelled with Gaussian functions.</p><p>  <strong>Results</strong> Shortened T1 relaxation times were seen solely in the submandibular glands of patients with SCD (747.5 ± 54.8 ms vs 807.1 ± 38.3 ms, p < 0.001). Slight T2 and secular T2 shortening were seen in the parotid gland however, this difference was not significant (p = 0.07). The sublingual gland showed no changes under MR relaxometry. There was no difference in glandular volumes, and no correlation was demonstrated between history of blood transfusion and salivary gland relaxometry. </p><p> <strong>Conclusions</strong> Patients with SCD exhibited changes in quantitative MRI T1 relaxometry histograms of the submandibular glands. </p><hr><p></p><p> <strong>Source: </strong>Dentomaxillofacial Radiology Journal</p><p><a href="http://dmfr.birjournals.org/content/41/8/630.abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> sickle cell anaemia, magnetic resonance imaging, salivary glands ,submandibular gland 0 0 http://idai.ir/browse.php?a_code=A-10-32-743&slc_lang=en&sid=1 J Liao joseph.h.liao@gmail.com 10031947532846003133 10031947532846003133 Yes Boston Medical Center, Boston University School of Medicine, Boston, MA, USA N Saito 10031947532846003134 10031947532846003134 No Boston Medical Center, Boston University School of Medicine, Boston, MA, USA A Ozonoff 10031947532846003135 10031947532846003135 No Boston University School of Public Health, Boston, MA, USA H Jara 10031947532846003136 10031947532846003136 No Boston Medical Center, Boston University School of Medicine, Boston, MA, USA M Steinberg 10031947532846003137 10031947532846003137 No Boston Medical Center, Boston University School of Medicine, Boston, MA, USA O Sakai 10031947532846003138 10031947532846003138 No Boston Medical Center, Boston University School of Medicine, Boston, MA, USA