en پریودنتولوژی Periodontology پژوهشي Research <p> <strong>Background:</strong> Many environmental and genetic factors are known as factors that increase the susceptibility to periodontitis. As IL-8 is a chemokine that mediate the inflammatory process in periodontal disease, we decided to evaluate the effect of its polymorphism on chronic and aggressive periodontitis. </p><p> <strong>Materials and Methods:</strong> In this cross-sectional study DNA was isolated from the whole blood of 107 periodontitis patients and 199 healthy individuals. All samples were genotyped for the IL-8 polymorphisms using the polymerase chain reaction with sequence specific primers. The distribution of the interleukin-8 genotype and allele frequencies in control and disease groups was analyzed by the Chi-square test and a P-value of < 0.05 was considered statistically significant. </p><p> <strong>Results:</strong> The findings revealed that the allele and genotype frequencies of A2767T, T11722T2, and C781T polymorphism of IL-8 gene were not significantly differed between controls and patients. However, there was a significant difference in the genotype frequencies of IL-8 A251T (P < 0.0001), G396T (P < 0.0001), and C1633T (P < 0.0001) gene polymorphism between the patient and the control groups. Additionally, there was a significant difference in the genotype frequencies of C1633T (P < 0.05) polymorphism of IL-8 gene between the aggressive and chronic periodontitis. </p><p> <strong>Conclusion:</strong> IL-8 gene polymorphism may be protective against periodontitis. </p><hr><p></p><p> <strong>Source: </strong>Dental Research Journal </p><p><a href="http://drj.mui.ac.ir/index.php/drj/article/view/492" target="_blank"><font color="#0033ff"> Full Text</font></a></p> Aggressive periodontitis, chronic periodontitis, genetic polymorphism, interleukin-8 0 0 http://idai.ir/browse.php?a_code=A-10-32-712&slc_lang=en&sid=1 Behzad Houshmand 10031947532846002998 10031947532846002998 No School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, iran Mehrdad Hajilooi 10031947532846002999 10031947532846002999 No School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran Alireza Rafiei 10031947532846003000 10031947532846003000 No Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran Mohsen Bidgoli 10031947532846003001 10031947532846003001 No Dental Research Center, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran Sara Soheilifar sara.soheilifar@umsha.ac.ir 10031947532846003002 10031947532846003002 Yes Dental Research Center, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran