en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p><strong> Background:</strong> Tumor growth depends on cell proliferation and new blood vessels formation. In spite of the important role of these events in tumor progression , their relationship to patient gender and age is not clear.<br><strong>Aim :</strong> This study conducted to examine the relationship between VEGF and Ki67expression to gender and age of patients that involved with oral squamous cell carcinoma (OSCC) . <br><strong>Method :</strong>The expression of VEGF and Ki-67 were examined immunohistochemically on 23 archival tissue of Well-differentiated OSCC. The relation between VEGF and Ki-67 expression with gender and age were studied. VEGF and Ki-67 expression was assessed by obtaining the total score (TS = proportion score× Staining index). T-test and linear correlation tests were performed for statistical analysis. P≤0.05 was considered significant.<br><strong>Results :</strong> VEGF and Ki67 were expressed in all samples . For VEGF expression , the lowest and highest TS were 0 and 9 in females , 0 and 6 in males. Considering the patients age , the lowest and highest TS were 0 and 9 in ≤60 , 0 and 6 in >60 groups.<br>For ki-67 expression , the lowest and highest TS were 1 and 9 in females , 1 and 6 in males. Considering the patients age , the lowest and highest TS were 1 and 9 in both ≤60 and >60 groups. The expression of VEGF and Ki-67 between male and females and different ages was not significant(p=0.43,p=0.88, p=0. 67, p=0.88) . <br><strong>Conclusion :</strong> The expression of VEGF and Ki-67 demonstrated in SCC of oral cavity . The expression of VEGF and Ki-67 between male and females and different ages was not significant . </p><hr><p></p><p> <strong>Source:</strong> Journal of Dental Research, Dental Clinics, Dental Prospects</p><p><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/313" target="_blank"><font color="#0000cc"> Full text</font></a></p> Vascular Endothelial Growth Factor (VEGF), Ki-67 antigen , Oral Squamous Cell Carcinoma(OSCC) 0 0 http://idai.ir/browse.php?a_code=A-10-32-539&slc_lang=en&sid=1 Noushin Jalayer Naderi 10031947532846002197 10031947532846002197 Yes Farrokh Tirgari 10031947532846002198 10031947532846002198 No Farzin Esmaili 10031947532846002199 10031947532846002199 No Faranak Paktinat 10031947532846002200 10031947532846002200 No Zahra Keshavarz 10031947532846002201 10031947532846002201 No