en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> Gorlin-Goltz syndrome is an uncommon autosomal dominant inherited disorder, which is<br>characterized by multiple odontogenic Keratocysts and basal cell carcinomas, skeletal, dental,<br>ophthalmic, and neurological abnormalities, intracranial ectopic calcifications of the falx cerebri,<br>and facial dysmorphism. Pathogenesis of the syndrome is attributed to abnormalities in the long<br>arm of chromosome 9 (q22.3-q31) and loss or mutations of human patched gene (PTCH1 gene).<br>Diagnosis is based upon established major and minor clinical and radiological criteria and ideally<br>confirmed by deoxyribo nucleic acid analysis. We report a case of a 9-year-old girl presenting<br>with three major and one minor feature of Gorlin-Goltz syndrome. Radiologic findings of the<br>syndrome are easily identifiable on Orthopantomogram, chest X-ray, and Computed tomography<br>scans. These investigations prompt an early verification of the disease, which is very important to<br>prevent recurrence and better survival rates from the coexistent diseases.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/903"><font color="#0000ff"> Full text</font></a> </p> Calcification of falx cerebri, fused ribs, Gorlin-Goltz syndrome, odontogenic keratocyst 0 0 http://idai.ir/browse.php?a_code=A-10-32-387&slc_lang=en&sid=1 Priya Shirish Joshi sangeetakov@yahoo.co.in 10031947532846001626 10031947532846001626 Yes Department of Oral Pathology and Microbiology, Vasantdada Patil Dental College and Hospital, Kavalapur, Sangli, India Vijay Deshmukh 10031947532846001627 10031947532846001627 No Department of Oral and Maxillofacial Surgery, Yashavantrao Chavan Memorial Dental College, Ahmednagar, Pune, India Someshwar Golgire 10031947532846001628 10031947532846001628 No Department of Oral Pathology and Microbiology, Vasantdada Patil Dental College and Hospital, Kavalapur, Sangli, India