en پریودنتولوژی Periodontology پژوهشي Research <p><strong> Background</strong>: Tissue engineering principles can be exploited to enhance alveolar and peri-implant<br>bone reconstruction by applying such biological factors as platelet-derived growth factors. The<br>objective of the present study is to investigate the effect of autologous plasma-rich in growth<br>factors (on the healing of peri-implant bone in canine mandible).<br><strong>Materials and Methods</strong>: In this prospective experimental animal study, two healthy canines of<br>the Iranian mix breed were selected. Three months after removing their premolar teeth on both<br>sides of the mandible, 12 implants of the Osteo Implant Corporationsystem, 5 mm in diameter<br>and 10 mm in length, were selected to be implanted. Plasma rich in growth factors (PRGF) were<br>applied on six implants while the other six were used as plain implants without the plasma. The<br>implants were installed in osteotomy sites on both sides of the mandible to be removed after 4<br>weeks with the surrounding bones using a trephine bur. Mesio-distal sections and implant blocks,<br>50 μ in diameter containing the peri-implant bone, were prepared By basic fuchin toluidine-bluefor<br>histological and histomorphometric evaluation by optical microscope. The data were analyzed using<br>Mann-Whitney Test (P<0.05).<br><strong>Results:</strong> The bone trabeculae and the type of bone generation in PRGF and control groups had<br>no statistically significant differences (P=0.261, P=0.2) although the parameters showed higher<br>measured values in the PRGF group. However, compared to the control, application of PRGF had<br>significantly increased bone-to-implant contact (P=0.028)<br><strong>Conclusion:</strong> Based on the results, it may be concluded that application of PRGF on the surface<br>of implant may enhance bone-to-implant contact.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/902"><font color="#0000ff"> Full text</font></a> </p> Bone-to-implant contact, histological, histomorphometric, platelet-rich plasma growth factor 0 0 http://idai.ir/browse.php?a_code=A-10-32-386&slc_lang=en&sid=1 Reza Birang 10031947532846001622 10031947532846001622 No Department of Periodontics and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Alireza Torabi 10031947532846001623 10031947532846001623 No Periodontist, Dental School, Islamic Azad of Tehran university, Tehran, Iran Mohammad Shahabooei shahabooei@dnt.mui.ac.ir 10031947532846001624 10031947532846001624 Yes Department of Periodontics and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Mansour Rismanchian 10031947532846001625 10031947532846001625 No Department of Periodontics and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran