en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> Background: Oral manifestations are frequently the initial signs of acute leukemia, prompting<br>the patient to consult the dentist first. The gingival tissue is one site commonly involved either<br>by leukemic infiltration or by inflammatory reactive hyperplasia, causing gingival enlargement. The<br>gingival infiltration may also be present without gingival enlargement. Early recognition of clinical<br>findings in the oral cavity leads to its timely diagnosis and management. Since biopsy is highly<br>contraindicated, gingival fine needle aspiration cytology was performed to assess its diagnostic<br>value in detecting gingival infiltration in acute leukemia patients.<br>Materials and Methods: Fifty patients of acute leukemia received clinical and gingival cytological<br>examination. The cases were diagnosed based on bone marrow aspiration findings and classified<br>according to the French–American–British criteria. The absence or presence of intraoral findings<br>was recorded. Site for gingival fine needle aspiration cytology was selected.<br>Results: Leukemic gingival infiltration was found to be more common in acute lymphoblastic<br>leukemia, while the characteristic oral findings were seen more commonly in acute myeloblastic<br>leukemia. All the eight cases of acute lymphoblastic leukemia that were positive for leukemic<br>gingival infiltration showed no clinical evidence of gingival enlargement. In terms of leukemic gingival<br>infiltration, L2 subtype was the only subtype involved, while M5 was more commonly involved than<br>M4 subtype. Two cases of L2 subtype showed gingival enlargement due to local factors like plaque/<br>calculus rather than due to leukemic infiltration.<br>Conclusion: The technique was found to be safe and of definitive diagnostic value in detecting<br>gingival infiltration in acute leukemia patients.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/900"><font color="#0000ff"> Full text</font></a> </p> Acute leukemia, fine needle aspiration cytology, gingiva 0 0 http://idai.ir/browse.php?a_code=A-10-32-384&slc_lang=en&sid=1 A. Sri Kennath J. Arul kenkajal@gmail.com 10031947532846001615 10031947532846001615 Yes Departments of Oral and Maxillofacial Pathology, Best Dental Science College, Madurai, Tamil Nadu, India Sonika Verma 10031947532846001616 10031947532846001616 No M. M. College of Dental Sciences and Research, Mullana, Haryana, India Shaheen Ahmed 10031947532846001617 10031947532846001617 No C. K. S. Teja Institute of Dental Sciences and Research, Tirupathi, Andhra Pradesh, India A. Sri Sennath J. Arul 10031947532846001618 10031947532846001618 No Department of Psychiatric Medicine, Gokulam Medical College, Trivandrum, Kerala, India